Irrigation at critical growth stages could improve wheat yield significantly. A study was conducted during 2000–2002 to determine effect of different irrigation levels on growth and yield of different wheat genotypes in the province of Sindh. The trial was laid out in split block design at Wheat Research Institute, Sindh, Sakrand, in which four irrigation treatments I3 (irrigation at crown root, booting and soft dough stage), I4 (irrigation at crown root, tillering, booting and soft dough stage), I5 (irrigation at crown root, tillering, booting, anthesis and soft dough stage) and I6 (irrigation at crown root, tillering, booting, anthesis, soft dough and hard dough stage) were in blocks and six wheat genotypes; V–7001, V–7002, V–7004, NARC–9 and CO–9043 and Abadgar–93 were planted. Number of irrigation did not have any significant effect on plant height, whereas plant height was affected significantly in different cultivars. Application of five irrigations at different wheat growth stages resulted in higher spike length, higher number of grains and wheat grain yield. Wheat variety Abadgar–93 and V–7004, had taller plants in comparison with cultivars NARC–9 and V–7004 however, wheat grain yield was not affected significantly among different cultivars.