Studies on the comparative effect of different plant extracts (neem seed, neem leaves and tobacco leaves) and insecticide permethrin dust alone or mixed with dung, were conducted against red pumpkin beetle in the field at National Agricultural Research Centre, Islamabad during kharif 2008. Permethrin (0.5%) alone or mixed (0.05%) with dung ash as dust controlled the attack of red pumpkin beetle on the crop with no mortality of plants. Highest mortality of plants due to foliage eating by red pumpkin beetle was observed in control where no permethrin was applied. None of the plant extracts tested in this study as dust alone or mixed with dung ash was effective in controlling red pumpkin beetle attack. Permethrin dust (0.5%) alone and ash + permethrin dust (2000: 1 a.i w/w) gave a significantly higher yield of 18.07 and 18.63 t ha-1 in cucumber, respectively.