Solanum khasianum and Solanum mammosum are well-known for their solasodine content, which is the precursor for the preparation of cortisone. To assess the possibilities of their acclimatization and cultivation, yield trials with various spacings were conducted for three consecutive year i.e., from 1982 to 1984 at Peshawar. S. mammosum though gave higher yield of fresh berries (1033 kg/ha) as compared to S. khasianum (746kg/ha) but S. mammosum was found to be highly susceptible to black shank disease caused by Phytophthora spp. during 1984, whereas S. khasianum was resistant. Chemical analysis of berries depicted higher percentage of solasodine content (2.65%) in S. khasianum as compared to S.mammosum (1.5%). The results of chemical analysis are in conformity with Atal and Kapoor 1977.Spacing of 75 x 75 cm was found to be suitable in both the species. S. khasianum on the basis of better performance and resistance to black shank disease could be recommended for cultivation by pharmaceutical concerns under Peshawar climatic conditions.