Experiments were carried out to determine the optimum period of growth, effect of planting season and application of N&P alone or in combination on the yield of Dioscorea diltoidea rhizomes at Kuza Gali, its natural habitat. Results indicated that yield of rhizomes significantly increased with the increase in duration of time. The yield was optimum after 6 years growth period followed by progressive decline in yield of rhizomes harvested after 8th and 10th years of growth. Monsoon planting provided more number sprouts and higher yield of rhizomes as compared to fall planting. Application of NP fertilizer at 135 kg N and 65kg P/ha basal dose gave higher yield as compared to control.