The presentation is a part of an ethno botanical research work conducted Margalla Hills National Park. The inhabitants of the park have always used medicinal plants for various ailments and have for a long time been dependent on surrounding plant resources for their food, shelter, fodder, health care and other cultural purposes. However, encroaching industrialization and the accompanying changes in their life styles are responsible for the decline in the local practice of uses of these plants before the information is lost. About 100 informants were interviewed in this regard. In total 27 species of trees and 24 species of shrubs were recorded as used medicinally by inhabitants of the park. Among these 10 species of trees and 5 species of shrubs are being sold in the local market. Berberis lyceum Royle is found vulnerable to harvesting. Acacia modesta Wall, A. nilotica (L.) Delile, and Dodonaea viscous (L) Jacq. Are found under pressure of being used as fuelwood.