The emerging technology of nanoneedle employ the nanoneedle for the penetration in cell membrane to investigate and manipulate biomedical procedures in the living cells. This study presents a simulated methodology on the basis of fuzzy logic for flow rate of drug delivery through a nanoneedle for drug delivery. The outflow rate is measured as 1.32 mL/min through MATLAB simulation. The measurements are verified by the Mamdani’s model and the previous research. The simulated results given in this study specifies that the fuzzy logic deliver an effective modeling presentation by showing good agreement with the parametric measurements. Therefore, Fuzzy Logic is an alternate method to obtain outflow rate and other parameters for nanoneedles. This nanoneedle technology is revealed as a dominant and multipurpose technology. It can deal with many new customs to discover biomedical procedures with new bio-physical characteristics of the living cells.