Articles
3,478 open-access articles · page 66 of 174
Research ArticleEffect of miR-4728-3p on the Regulation of PTEN in Apatinib-resistance SCLC Cell Line
Fang Chen
To explore the effects of microRNA (MicroRNA, miR)-4728-3p targeting regulation of phosphatase and tensin homology deleted on chromosome 10 (PTEN) on the drug resistance of small cell lung cancer (SCLC) to apatinib. Human SCLC cell line H69 was purchased from…
10 Apr 2023DOI 10.17582/journal.pjz/20210202110210
Research ArticleChanges in the Intestinal Microbes of Wild Spermophilus dauricus (Rodentia: Sciuridae) in Different Periods of Hibernation (A Model of Gut Ischemic Reperfusion Injury)
Chun Shi, Juanjuan Guo, Meng Li, Qi Yang, Jingang Li
Reperfusion injury after intestinal ischemia and hypoxia is a complex and comprehensive disease with a poor prognosis and high fatality rate. However, whether it can promote or slow down intestinal ischemia-reperfusion injury remains unclear. Spermophilus daur…
10 Apr 2023DOI 10.17582/journal.pjz/20220531140522
Research ArticleThe Upregulated Exosome Protein ET-1 Induces the Increased Level of Ang-II and Contributes to the Progression of Pre-Eclampsia
Yun Zhang
Pre-eclampsia (PE) is one of the leading complications of pregnancy that contributes to the increasing morbidity and mortality. However, the effects of exosomes secretion and expression of ET-1 and Ang-II on PE progression has not been fully investigated. The…
10 Apr 2023DOI 10.17582/journal.pjz/20220713030715
Research ArticleHsa_circ_0009910 Regulates Cisplatin Sensitivity of Ovarian Cancer Cells by Targeting miR-455-5p /PAX2
Lei Jiang, Yi Huang, Runfeng Yang, Xiaohui Jiang, Hao Yan
The objective of this study was to investigate whether Hsa_circ_0009910 regulates cisplatin sensitivity of ovarian cancer cells by regulating the expression of miR-455-5p /PAX2. The expressions of circ_0009910, miR-455-5p and PAX2 mRNA in HOSEPiCs and ovarian…
18 Mar 2023DOI 10.17582/journal.pjz/20201031131033
Research ArticleAnti-Stress Activity of Oviductus Ranae in Mice with Acute Stress Based on Network Pharmacology
Zhe Lin, Yumo Li, Yuchen Wang, Yuechen Li, Ke Pei, Guangfu Lv et al.
Stress is a state of threatened homeostasis that causes the body to release the hormone cortisol produced by the adrenal glands. Oviductus ranae (OR) is an animal based raw material of folk medicine which plays a variety of activities. However, its anti-stress…
18 Mar 2023DOI 10.17582/journal.pjz/20210818020819
Research ArticleEffect of Electroacupuncture and Transcutaneous Electrical Acupoint Stimulation on Tumor Related T Cells
Yuhua Chen, Song Lu
Objective of this study was to determine the effect of electroacupuncture and transcutaneous electrical acupoint stimulation on tumor-related T cells. C57BL/6J mice used in the study were randomly divided into control and electrical stimulation group. The tumo…
18 Mar 2023DOI 10.17582/journal.pjz/20210125090155
Research ArticleIdentification of Absorbed Constituents and their Metabolites Related to Estrogen-Like Activity of Total Glycosides of Cistanche deserticola in Rat Serum
Yang Hu, Jingxin Ding, Beilei Xu, Xiangming Sun, Guoyu Li, Hui Song et al.
Cistanche deserticola Y. C. Ma is a kind of traditional Chinese medicine and food raw material with estrogen-like effect; its active ingredients are glycosides. To explore the absorbed constituents of total glycosides (TGs) in vivo and its estrogen-like activi…
18 Mar 2023DOI 10.17582/journal.pjz/20210615060610
Research ArticleEffect of Dietary Inclusion of Soybean Hulls in the Diet on Feed Proximate Analysis, Egg Quality Parameters and Economics during Peak Egg Production Stages in Laying Hens
Muhammad Shuaib, Abdul Hafeez, Ziaul Islam, Assar Ali Shah, Saad Ullah
The study was designed to determine the effect of varying levels of soybean hulls inclusion in the diet of brown layer on, feed proximate analysis, egg quality, and economies during peak egg production period with different phases (phase-1=week 29 to 32, phase…
18 Mar 2023DOI 10.17582/journal.pjz/20220118200147
Research ArticleHabitat Suitability Modeling of Asiatic Black Bear (Ursus thibetanus) in Azad Jammu and Kashmir, Pakistan
Usman Ali, Basharat Ahmad, Riaz Aziz Minhas, Muhammad Kabir, Muhammad Siddique Awan, Liaqat Ali Khan et al.
Effective conservation and management of Asiatic black bear Ursus thibetanus requires the identification and in-depth knowledge of suitable habitats. Habitat suitability models (HSMs) have wide use in the understanding of niche requirements, hence prioritizing…
18 Mar 2023DOI 10.17582/journal.pjz/20220404120401
Research ArticleGenetic Diversity and its Impact on Post Translational Modifications of PKC and bml-Beta Tubulin Homolog Proteins in Different Species and Strains of Sordaria
Ayesha Ahsan, Rabia Arif, Samina Nazir, Muhammad Saleem, Memunna G. Shahid
Protein Kinase C (PKC) and tubulin homologs are present in all eukaryotes and play significant role in growth, development and cell differentiation through phosphorylation and de-phosphorylation of other proteins. In this study, we have amplified PKC and beta…
16 Mar 2023DOI 10.17582/journal.pjz/20180824120824
Research ArticleEffect of Dietary Pongamia pinnata on Immunity and Gut Microflora in Broiler Chickens
Ahmed Ali Chandio, Asghar Ali Kamboh, Nazar Ali Korejo, Riaz Ahmed Leghari, Muhammad Ali Chandio
Pongamia pinnata is an indigenous medicinal plant of Asia, which has long traditional use, having anti-inflammatory, anti-pyretic, anti-nociceptive, anti-oxidant, anti-ulcer, antihyperglycaemic and anti-microbial activities. The current investigation aimed to…
16 Mar 2023DOI 10.17582/journal.pjz/20211222071210
Research ArticleOphiotaenia tessellata sp. n. (Eucestoda: Proteocephalinae) from Natrix tessellata (Laurenti, 1768) (Serpentes: Colubridae) in Egypt
Irene S. Gamil, Dalia Fouad
Ophiotaenia tessellata sp. n. (Proteocephalidea: Proteocephalinae) is described from the intestine of the dice water snake Natrix tessellata (Laurenti, 1768) (Serpentes: Colubridae) collected from El Faiyoum Governorate, Egypt. Standard methods of collection o…
16 Mar 2023DOI 10.17582/journal.pjz/20190803150801- Research Article
Effect of Vitamin E Supplementation on Growth Performance, Immune Function, Serum Biochemical Parameters, and Antioxidant Capacity of Swan Goose (Anser cygnoid)
Jianli Xiong, Hongtao Ren, Guanglu Li, Xiaochan Gao, Yong Huang, Shiyang Gao
The present study aimed to investigate the effects of dietary vitamin E (VE) supplementation on the growth performance, immune function, serum biochemical parameters, and antioxidant capacity of growing swan geese (Anser cygnoid). 240 four-week-old healthy swa…
16 Mar 2023DOI 10.17582/journal.pjz/20200703020702 
Research ArticleDetection and Phylogenetic Analysis of Infectious Bursal Disease Virus Based on both Genome Segments A and B Isolated from Backyard Poultry Punjab, Pakistan
Syeda Fakhra Waheed, Asim Aslam, Muti-ur-Rehman Khan, Kamran Ashraf, Beenish Zahid
In recent years, the re-emergence of virulent strains of infectious bursal disease virus (IBDV) has resulted in substantial economic losses in Pakistan despite mass and intense vaccination regimens. Infectious bursal disease (IBD) is one of the most important…
16 Mar 2023DOI 10.17582/journal.pjz/20211230141208
Research ArticleDairy Productivity of Holstein Cows of Different Genetic Lines in the Conditions of Kostanay Region of Kazakhstan
Gulzhan Kalenovna Mussayeva, Alikhan Meldebekovich Meldebekov, Nurgul Alikhanovna Meldebekova, Gulshat Imanzhankyzy Shaykamal, Batyrkhan Azimkhanovich Buralkhiyev, Nurkuisa Mirzabekovich Rametov et al.
This article presents a comparative characteristic of cows’ dairy productivity in the context of three lines: Reflection Sovereign and Wis Burke Ideal and Osborndale Ivanhoe in the conditions of the breeding farm of Kostanay region. Studies on lactating…
16 Mar 2023DOI 10.17582/journal.pjz/20210818080851
Research ArticleFood Analysis of Indian Gerbil (Tatera indica, Hardwicke, 1807) in Pothwar, Pakistan
Amber Khalid, Amjad Rashid Kayani, Muhammad Sajid Nadeem, Muhammad Mushtaq, Mirza Azhar Beg, Surrya Khanam
Indian gerbil (Tatera indica) belongs to family Muridae, is considered an important agricultural pest and causes damage to the crops in Pakistan including Pothwar. Information about the diet of the rodents is prerequisite for the better management of pest spec…
14 Mar 2023DOI 10.17582/journal.pjz/20211106131150
Research ArticleDifferential DNA Methylation of Growth Factors in Antlers of Sika Deer and Reindeer
Jian-Cheng Zhai, Sheng-Nan Wang, Qiang-Hui Wang, Yan-Ling Xia, Wei-Shi Liu, Ya-Jie Yin et al.
Reindeer is the only deer species in both sexes grow antlers. Many apparent differences exist in antlers of female and male reindeer and sika deer. Insulin like growth factor 1 (IGF1), Keratinocyte growth factor (KGF) and Nerve Growth Factor (NGF) are essentia…
14 Mar 2023DOI 10.17582/journal.pjz/20190718030701
Research ArticleMethanolic Extract of Neem Plant Inhibits NS3 and NS5A Nonstructural Proteins of HCV 3A Genotype
Ubaida Hussain, Amtul Jamil Sami, Shazia Rafique, Muhammad Idrees khan, Ahmad Ali Shahid
Hepatitis C virus (HCV) has infected an approximate of 170-200 million people worldwide. This unique RNA virus escapes the immunity in most infected people and forms a chronic infection which can progress to liver cirrhosis, fibrosis, hepatic cancer, and death…
14 Mar 2023DOI 10.17582/journal.pjz/20220322140354
Research ArticleAlantolactone Inhibits A2780 Cell Growth through Glycolysis Inhibition and Ros-Induced Apoptosis and Overcomes Cisplatin Resistance
Chenchen Liu, Tong Wang, Muhammad Khan, Xiaolin Cui, Yongming Li
Alantolactone (ALT) a biologically active sesquiterpene lactone compound has been shown to exhibit anticancer activity against a series of human cancers through multiple mechanism. However, the anticancer effects of ALT against ovarian cancer remains unknown.…
14 Mar 2023DOI 10.17582/journal.pjz/20220124120112
Research ArticleGenetic Diversity in Bibrik Sheep of Pakistan Elucidated through Molecular Characterization
Jameel Ahmed, Mohammad Masood Tariq, Nadeem Rashid, Asim Faraz, Majed Rafeeq, Irfan Shehzad Sheikh et al.
Bibrik sheep is found vastly in Baluchistan province in Pakistan. Randomly sampled animals of this breed were subjected to genetic analysis using ovine molecular markers where fifteen sheep SSR genetic markers were employed for describing multiple-allelomorphi…
14 Mar 2023DOI 10.17582/journal.pjz/20210607170624