A total of 300 one day old Hubbard chicks were divided into 6 groups (GI-G6: 50 chicks/each) The Gl(control neither vaccinated nor treated), G2 vaccinated with NDV, G3 (vaccinated with MDV Rispen strain), G4 (vaccinated with MDV and NDV) , Group 5 vaccinated with MDV vaccine and treated with Curcuma Longa , and G 6 vaccinated with MDV, NDV and treated with Curcuma Longa . Chicks vaccinated with NDV vaccine received Hitciner B-l strain at 7th day of age then boosted with LaSota strain at 21st day of age in drinking water, while groups vaccinated with MDV vaccine (0.2ml/chick) at one day of age by SIC injection. Serum samples at 10, 14, 17, 21, 28, 35, and 42 of age for HI test against NDV. Heparinized blood samples at 10, 14, 17, 21, days of age for phagocytic activity of macrophages. All groups were challenged with vvNDV for detecting the protection percent. From this study it could be concluded that MDV vaccine has an immunosuppressive effect on chicks and this could be antagonized by immunostimulant as curcuma longa The surprising immuno-stimulatory effect of curcuma is in the induction of protection level 80% in treated but not NDV vaccinated group which equivalent to that group vaccinated with NDV vaccine only and not treated. From the obtained results we recommend the use of curcuma longa powder in poultry rations for enhancing the immune response against either field infection or vaccination.