A pot experiments were conducted on potato (Solanum tuberosum L.cv. cara) plants during the winter season at 2011 to investigation the abnormalities changes of potato leaflets and tubers infected with Potato virus Y. Anatomical features of terminal leaflets i.e. mean of thickness both, midrib zone, leaflet blade, upper epidermal layer, palisade and spongy tissues, length and width of protoxylem and metaxylem vessels were reduced. However, lower epidermal layer was increased. Stomatal characters i.e. number of stomata and length of stoma pore were increased, while, width of stoma pore, length and width of guard cells were reduced. Anatomical characters of tubers i.e. thickness cork layers was slightly increased, however, its number was sharp reduced compared with healthy tubers. Biochemical changes of potato tubers i.e. number of starch granules and total carbohydrate contents were non-significantly reduced as comparing to the healthy ones. As well as morphological characters i.e. size and tuber weight per plant were significantly reduced, however, its number was significantly increased as comparing to the healthy plant.