Avian influenza outbreak was firstly appeared in poultry reared in backyards or roofs of homes in Qaluobia & Giza governorates as many notifications were received by the General Organization of Veterinary Services (GOVSs) in February 2006. The disease was spread and recorded in chickens (foreign breeds , Balady , and hybrids ) , turkeys, ducks , geese and wild birds (from Giza Zoo) in 20 out of 26 (76.9 %) of the Egyptian governorates within few weeks. The number of confirmed farm cases was 840 farms (layers 327, Broilers 164, Balady 1 17, Saso 86, parents 84, turkeys 32, ducks 29 and grand parents l) and those of rural birds was 129 (home birds 1 19, wild birds 5, abattoir 3, shops sales live birds l, migratory bird l) from February to June 2006. The clinical picture of the disease were observed in infected birds that reared in farms and those of backyards (most of domestic birds) , or sold in shops (sells broilers or parrots The number of dead and culled birds in this outbreak was 34.4 millions with economical losses 2-3 billion dollars.