Articles
3,477 open-access articles · page 35 of 174
Short CommunicationClinical Evaluation of miR-155 and miR-21 Alone and in Combination for Diagnosis of Acute Progressive Cerebral Infarction
Linyu Zhou, Hong Yu, Yang Wang, Jianbing Bai, Chuanyan Bao, Yongqing Dai
The objective of this study was to clinical evaluate miR-155 and miR-21 alone and in combination for the diagnosis of acute progressive cerebral infarction (APCI). One hundred twenty-nine patients with acute cerebral infarction (ACI) were collected as observat…
12 Nov 2024DOI 10.17582/journal.pjz/20231211144026
Research ArticleEfficacy of Direct-Acting Antiviral in Treatment-Naive Chronic HCV Patients and in Those Previously Treated with Interferon and Ribavirin
Saima Younas, Quratulain Maqsood, Aleena Sumrin, Muhammad Umer Khan, Nazim Hussain
Pakistan has been ranked second highest in prevalence of hepatits C virus (HCV), all over the world. HCV genome depicts huge genetic variability resulting in seven different HCV genotypes (GTs) including around 90 sub types. Direct acting antivirals had revolu…
12 Nov 2024DOI 10.17582/journal.pjz/20230818135820- Research Article
Molecular Characterization of Multi Drug Resistant Mycobacterium tuberculosis Isolated from the Patients in the Hospital of Azad Jammu and Kashmir
Sumayya Aziz, Abdul Rauf, Gotam Das, Muhammad Zahid Latif, Mohammed Merae Alshahrani, Nawal E Al-Hazmi et al.
Globally, Pakistan, with population of around 231.4 million, is at 5th spot in the list of countries with the highest number of TB patients in the world and it is further challenged by an increase in drug-resistant TB cases. The present study was conducted to…
12 Nov 2024DOI 10.17582/journal.pjz/20190324160313 
ReviewClinical Expression Analysis of Serum miR-29b and miR-126 in Patients with Non-Proliferative Diabetic Retinopathy
Yan Liu, Xiao Zhang
Circulating miRNA remains stable and can affect glucose and lipid metabolism, inflammatory response, and angiogenesis pathways in diabetic patients by participating in energy metabolism, insulin synthesis, transportation, and signal transduction. It plays a cr…
12 Nov 2024DOI 10.17582/journal.pjz/20230525100537- Short Communication
Effect of Labetalol Combined with Nifedipine on the Efficacy, Renal Function and Hemodynamics of Hypertension in Pregnancy
Xia Huang, Jin Guo, Zhijun Fan, Yue Xiao, Lifang Li, Yuehua Luo
The objective of this study was to investigate the efficacy of labetalol in combination with nifedipine and its impact, renal function and hemodynamics of pregnancy-induced hypertension (PIH). The sample of ninety-eight patients diagnosed with PIH and treated…
12 Nov 2024DOI 10.17582/journal.pjz/20230916184025 
Short CommunicationExpression of Hemoglobin and Fibrinogen is Correlated with the Attack of Acute Arterial Embolism of the Lower Extremity
Li Nanlin, Liu Huijun, Ma Han, Ma Yanshou, Lv Fengquan, Dong Xiangyuan et al.
The objective of this study was to analyze the expression of hemoglobin and fibrinogen in acute lower extremity arterial embolism and its correlation with acute lower extremity arterial embolism. One hundred and twenty patients with acute lower extremity arter…
12 Nov 2024DOI 10.17582/journal.pjz/20220720190753
Research ArticleEffect of Pyrotinib on Levels of Tumor Markers in Patients with HER2-Positive Breast Cancer
Biao Zhong, MengMeng Zou, Jie Zeng, Juan Bai, YongJun Deng, Xin Li et al.
Exploring effective treatment regimens for patients with HER2-positive breast cancer (HPBC) is of significant importance. Pyrotinib is a small-molecule tyrosine kinase inhibitor (TKI) developed in China and irreversibly binds to human epidermal growth factor r…
12 Nov 2024DOI 10.17582/journal.pjz/20240204075341
Research ArticleMolecular Metabolism in Treatment of High Altitude Polycythemia with Duoxuekang Capsule
Jia Nie, Ze Weng Yong Zhong, Di Wang, Ming Jian Li
The objective of this study was to explore the molecular metabolic mechanism of Duoxuekang capsule curing high altitude polycythemia (HAPC) from two aspects of efficacy and mechanism. Sixty SPF grade male SD rats aged 1 month were purchased from the experiment…
12 Nov 2024DOI 10.17582/journal.pjz/20240128104955
Research ArticleStudies on the Mitochondrial tRNA Gene Variants in Patients with Coronary Artery Disease and Pathogenicity Assessment by in silico Analysis
Fayaz Khan, Aziz Uddin, Hisham N. Altayb, Bibi Nazia Murtaza, Sajid Ul Ghafoor, Faisal Imam et al.
Mutations in mitochondrial DNA (mtDNA) have been associated with many pathological conditions including cardiovascular diseases. In the present study, we have evaluated the mutations in the mitochondrial tRNA genes for leucine, threonine and proline in patient…
12 Nov 2024DOI 10.17582/journal.pjz/20231226090544- Short Communication
An Analysis of Risk Factors for Asthenospermia: A Hospital-Based Study in China
Chengyuan Dong, Jianxin Sun
The objective of this study was to explore the influencing factors of asthenospermia. Electronic medical record and semen samples were collected from 201 male patients in The Fourth People’s Hospital of Taizhou from November 2021 to March 2023. Multivari…
12 Nov 2024DOI 10.17582/journal.pjz/20231111042600 
Research ArticleExploring Potential Novel Causal Genes for Chronic Kidney Disease
Fangyi Hao, Tian Tian, Zhen Yang, Jiaxin Zheng
Functional genes underlying chronic kidney disease (CKD) remain unclear. This work explored susceptibility genes related to serum creatinine (Scr) and CKD through Mendelian randomization (MR) analysis.Data from genome-wide association study (GWAS) were selecte…
12 Nov 2024DOI 10.17582/journal.pjz/20230817064609
Research ArticleExploring Helicobacter pylori’s Impact on Clinical Manifestations and Gastroesophageal Reflux Disease Spectrum
Syed Rafiq Hussain Shah, Atta Ullah, Dhafer Hazip Gaber Alwayli, Jiaxu Liang, Tayyab Saeed Akhter, Faisal Rasheed et al.
Gastroesophageal reflux disease (GERD), a disorder resulting from the retrograde flow of gastric contents into the esophagus, affects an estimated 10–30% population worldwide. Several pathophysiological factors influence the development and the course of…
12 Nov 2024DOI 10.17582/journal.pjz/20230603100611
Short CommunicationImmunoregulatory Effect of Toll Like Receptor 9 Signaling Pathway in Neonatal Acute Lung Injury
Jun Mei
The purpose of this study was to investigate the impact of toll like receptor 9 (TLR9) signaling pathway and its immunoregulatory roles in neonatal acute lung injury (NALI) , laying a theoretical basis for the clinical therapy of NALI. Forty peripheral blood m…
12 Nov 2024DOI 10.17582/journal.pjz/20240121195923- Short Communication
Expression of Serum miRNA-137 in Women with Gestational Diabetes and its Relationship with Neonatal Hyperbilirubinemia
Meixiang Li, Meiyan Liu, Xuehua Sun, Juan Li
Diabetes is the most common endocrine disease in pregnancy, and identifying the risk factors of gestational diabetes mellitus (GDM) helps to discover women who are at risk of neonatal jaundice in the future. The purpose of this study was to investigate the exp…
12 Nov 2024DOI 10.17582/journal.pjz/20231012130923 - Short Communication
ω-3PUFA Inhibit Hepatic Fibrosis by Activating LKB1-AMPK Signal Pathway
Genfei Zhu, Xiaoqing Wu, Xianzhong Qian, Hong Hong
Hepatic stellate cell (HSC) lines were cultured in vitro and treated with different concentrations of Ω-3PUFA. The effects of Ω-3PUFA on the survival rate of HSCs were detected by MTT, and the α-SMA, collagen I, TIMP-1 and MMP-13 proteins wer…
12 Nov 2024DOI 10.17582/journal.pjz/20230804161622 - Research Article
Effect of Moringa oleifera Leaf Meal on Mineral Contents of Labeo rohita Fingerlings
Muhammad Zubair-ul-Hassan Arsalan, Syed Makhdoom Hussain, Basharat Ali, Bilal Ahmad, Muhammad Qurban, Adan Naeem et al.
Fish meal, a highly digestible source of protein in aqua feed, has not been readily available to fulfill the need for sustainable aquaculture production due to its limited supply and high price. So, the aim of this study was to develop more sustainable and eco…
11 Nov 2024DOI 10.17582/journal.pjz/20230413200442 - Research Article
Protective Effect of Shengdi-Cogongrass Decoction on Patients with Blood Heat Psoriasis
Duo Yuan, Bin Shi, Yanhua Tu
Shengdi-cogongrass decoction (SCD) is a traditional Chinese medicine formula, mainly composed of raw Rehmannia glutinosa (RG) and lalang grass rhizome (LGR). However, little is known about the molecular pharmacological activity of Shengdi-cogongrass on blood h…
11 Nov 2024DOI 10.17582/journal.pjz/20231215095814 
Research ArticleAlkB Homolog H5 Attenuates TGF-β1-Induced Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells via Regulating Zinc Finger E-box Binding Homeobox 1
Yunzhi Lin, Jing He, Xingwei Wu, Qian Shi
There is a relationship between proliferative vitreoretinopathy (PVR) and epithelial-mesenchymal transition (EMT) of Retinal pigment epithelium (RPE). The objective of this study was to investigate the role of AlkB homolog H5 (ALKBH5) in regulating EMT of RPE…
11 Nov 2024DOI 10.17582/journal.pjz/20231003105054
Research ArticleCarvacrol Induces Doxorubicin-Resistant Breast Cancer Cell Apoptosis via Inhibition of the PI3K/Akt Pathway
Hu-Hu Chen, Jiao-han Zhou, Siat Yee Fong
Doxorubicin (Dox), a widely used chemotherapeutic agent for breast cancer, is often ineffective due to the development of Dox resistance, posing a significant challenge in cancer treatment. Carvacrol is a monoterpene phenol with diverse biological activities,…
11 Nov 2024DOI 10.17582/journal.pjz/20220421100442
Research ArticleAquaporin-9 Aggravates Lipopolysaccharides Induced Acute Lung Injury Via Facilitating M1-Like Macrophage Polarization
Jiajia Wan, Chi Zhang, Xiaodi Li, Longkang Liu, Linxiu Peng, Yuejian Liu et al.
Alveolar macrophages (AMs) play a crucial role in orchestrating lung inflammation in acute lung injury (ALI), which largely depends upon M1-like macrophage polarization. However, the underlying regulatory mechanisms remain incompletely elucidated. The present…
11 Nov 2024DOI 10.17582/journal.pjz/20240502043333