Articles
3,477 open-access articles · page 36 of 174
Research ArticleNodakenin Inhibits Aurka-Cxcl5 Axis Induced Autophagy and Apoptosis in Non-Small Cell Lung Cancer and Promotes Radiosensitivity of Cancer Cells
Xiaoming Wang, Rui Tian, Kunpeng Duan, Xu Zhang
The objective of this study was to explore the role of nodakenin inhibiting AURKA-CXCL5 induced autophagy, cell death and promoting radiosensitivity in non-small cell lung cancer (NSCLC). The expression of AURKA-CXCL5 was determined in HBE, A549, H460 and H129…
11 Nov 2024DOI 10.17582/journal.pjz/20231221082217
Research ArticleAquaporin-9 Aggravates Lipopolysaccharides Induced Acute Lung Injury Via Facilitating M1-Like Macrophage Polarization
Jiajia Wan, Chi Zhang, Xiaodi Li, Longkang Liu, Linxiu Peng, Yuejian Liu et al.
Alveolar macrophages (AMs) play a crucial role in orchestrating lung inflammation in acute lung injury (ALI), which largely depends upon M1-like macrophage polarization. However, the underlying regulatory mechanisms remain incompletely elucidated. The present…
11 Nov 2024DOI 10.17582/journal.pjz/20240502043333
Research ArticleIdentification of Therapeutic Targets and Prognostic Biomarkers Among Matrix Metalloproteinases in the Ovarian Cancer Microenvironment
Mao MeiYa, Sheng Yuehua, Ding Huiqing, Zheng Xiaojiao, Du Yongming
Ovarian cancer (OC) is one of the most common malignances with an ever-increasing incidence and high mortality. Cross-talk between cancer cells and interstitial cells exerts significant effects on ovarian and tumor development and is modulated in part by MMPs.…
11 Nov 2024DOI 10.17582/journal.pjz/20231205030220
Research ArticleDynamic Changes of Immune Cells and their Relationship with Prognosis in Late-Stage Gastric Cancer Patients During PD-1 Inhibitor Immunotherapy
Chunqin Tian, Lichun Cui, Xiaoyan Wang
The study aimed to investigate the dynamic changes in immune cells during the programmed death-1 (PD-1) inhibitor therapy in patients with late-stage gastric cancer (GC) and to analyze the correlation between these changes and patient prognosis. One hundred th…
11 Nov 2024DOI 10.17582/journal.pjz/20240116074340
Research ArticleGinsenoside Rh2 Reduces Inflammation of Ulcerative Colitis via Elevating microRNA-30a-5p
Suanyuan Zhang, Qing Ji, Xinglong Wu, Jinjing Wang, Jin Yao, Chengfang Li et al.
Ulcerative colitis (UC) is a kind of chronic inflammatory bowel disease, closely related to colon cancer. Ginsenoside Rh2 (GRh2) is a rare protopanaxadiol type triterpene saponins in ginseng, which has anti-inflammatory/cancer/diabetic impacts. To investigate…
11 Nov 2024DOI 10.17582/journal.pjz/20220217080248
Research ArticleAlkB Homolog H5 Attenuates TGF-β1-Induced Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells via Regulating Zinc Finger E-box Binding Homeobox 1
Yunzhi Lin, Jing He, Xingwei Wu, Qian Shi
There is a relationship between proliferative vitreoretinopathy (PVR) and epithelial-mesenchymal transition (EMT) of Retinal pigment epithelium (RPE). The objective of this study was to investigate the role of AlkB homolog H5 (ALKBH5) in regulating EMT of RPE…
11 Nov 2024DOI 10.17582/journal.pjz/20231003105054
Research ArticleCDX1 Gene Expression in Recurrent Spontaneous Abortion under Extracellular Regulatory Protein Kinase1/2 Signaling Pathway
Shouyan Cao, Aili Yan, Wenhua Zhang, Fangfang Li, Xiaoning Liu
The aim was to explore the mechanism of the gene expression of caudal-related homeobox transcription factor 1 (CDX1) in recurrent spontaneous abortion (RSA) based on the extracellular regulatory protein kinase 1/2(ERK1/2) signaling pathway. In this study, 25 n…
11 Nov 2024DOI 10.17582/journal.pjz/20231030152055
Research ArticleCarvacrol Induces Doxorubicin-Resistant Breast Cancer Cell Apoptosis via Inhibition of the PI3K/Akt Pathway
Hu-Hu Chen, Jiao-han Zhou, Siat Yee Fong
Doxorubicin (Dox), a widely used chemotherapeutic agent for breast cancer, is often ineffective due to the development of Dox resistance, posing a significant challenge in cancer treatment. Carvacrol is a monoterpene phenol with diverse biological activities,…
11 Nov 2024DOI 10.17582/journal.pjz/20220421100442- Research Article
Expression and Promoter Methylation Status of CDX1 and CDX2 Genes in Chinese Patients with Gastric Cancer
Zhihong Huang, Xuemei Zhang, Ling Li, Min Hu, Mo Chen, Qunchao Mei
Gastric cancer is a multifactorial disease, the fourth most common cancer in the world and the second cause of cancer death. Changes in gene expression levels are one of the most important factors in the occurrence of cancer. Gene promoter methylation changes…
11 Nov 2024DOI 10.17582/journal.pjz/20231204081600 
Research ArticleBioinformatics Analysis of Promoter Methylation and Clinical Significance of Tumor Suppressor Gene HOXA5 in Oral Cancer
Haichao Wang, Yi Liu, Jingwen Wu, Wenjing Wang, Hongyi Zhang, Cunjian Yi
The HOXA5 gene is an important tumor suppressor gene, which has the function of regulating cell cycle, proliferation, and differentiation. Down regulation or inactivation of HOXA5 expression occurs in a variety of malignant tumors such as oral cancer (OC) and…
11 Nov 2024DOI 10.17582/journal.pjz/20230803165114- Research Article
Analysis of High-Risk Factors of Stillbirth Among Pregnant Women in China
Xiaobo Wang, Haiyang Tang, Haizhen Dai, Qingyi Xiang, Jing Fang, Xiaoxia Bai
The objective of this study was to explore the high-risk factors of stillbirth after the two-child policy was fully opened. 327 cases of stillbirth were collected in the Obstetrics and Gynecology Hospital of Zhejiang University from January 2015 to December 20…
11 Nov 2024DOI 10.17582/journal.pjz/20230630110601 
Research ArticleEffects of Desflurane on Inflammatory Response and Cardiac Function During Cardiopulmonary Bypass in Cardiac Surgery
Jingjing Guo, Ruitong Niu, Shanshan Mu, Anshi Wu
The objective of this study was to investigate the effect of desflurane on inflammatory response and cardiac function during cardiopulmonary bypass in cardiac surgery. Thirty adult male Sprague-Dawley rats (body weight, 250-300g) were purchased from the Provin…
11 Nov 2024DOI 10.17582/journal.pjz/20230813075411- Research Article
Distribution of Pathogenic Bacteria of Postoperative Wound Infection and Early Prediction Value of Serum in Children with Hypospadias
Mimi Jin, Xiaoye Hu, Lijing Yu, Shuangli Zheng, Huishuang Huang, Fang Chen
The objective of this study was to investigate the distribution of pathogens and the early predictive value of serum in children with hypospadias. The sample consisted children with hypospadias between January 2019 and December 2021 at the Second Affiliated Ho…
11 Nov 2024DOI 10.17582/journal.pjz/20230602210624 - Research Article
Effect of Calcium Supplement Combined with Carbetocin on Postpartum Hemorrhage in Scarred Uterine Cesarean Section
Guoqing Lai, Youxia Dai, Yuling Lan
Cesarean section (CS) in scarred uterus pregnancies (SUPs) is a high-risk obstetric procedure often associated with the risk of postpartum hemorrhage (PH). The objective of this study was to investigate the effect of calcium supplement combined with Carbetocin…
11 Nov 2024DOI 10.17582/journal.pjz/20230911194048 
Research ArticleRelationship between Serum sEng, PLGF, Gal-1 Levels and Pregnancy Outcome in Pregnant Hypertensive Mothers during Pregnancy
Yanfang Wu, Lei Chen, Xiaoning Jia
The objective of this study was to observe the relationship between serum levels of soluble fms-like tyrosine kinase-1 (sEng), placental growth factors (PLGF), and galectin-1 (Gal-1) in hypertensive pregnant women during pregnancy and the pregnancy outcome. Th…
11 Nov 2024DOI 10.17582/journal.pjz/20230809065557
Research ArticleEffect of Somatostatin Combined with Modified Dachengqi Decoction on Intestinal Function and Inflammatory Factors (TNF-α, IL-6, and IL-8) in Acute Pancreatitis
Hong Sun, Jie Shao
This article aimed to evaluate the effect of somatostatin combined with modified Dachengqi decoction on the improvement of intestinal function in patients with severe acute pancreatitis (SAP), and to explore its effect on the levels of inflammatory factors. Si…
11 Nov 2024DOI 10.17582/journal.pjz/20230804172924- Research Article
Pathological Diagnostic Efficacy and Influencing Factors of Ovarian Tumour Using Cytological Smears Combined with Frozen Sections
Fang Li, Na Zhao, Dan Wu, Jingya Hei, Yuyang Pan
The objective of this study was to investigate the pathological diagnostic efficacy of applying cytological smears (CytS) combined with frozen sections (FroS) in patients with ovarian tumour (OT), and to study the relevant factors affecting the pathological di…
11 Nov 2024DOI 10.17582/journal.pjz/20230806091722 - Research Article
Association of Serum Inflammatory Factors and Hip Joint Scores with Adverse Prognosis After Internal Fixation in Patients with Femoral Neck Fractures
Hao Weng, Liang Zhu, Zhu Mei, Mingxian Wu, Qiang Xu
The objective of this study was to explore the relationship between adverse postoperative outcomes, changes in serum inflammatory factor levels, and hip joint functional scores in patients undergoing internal fixation for femoral neck fractures (FNF). A total…
11 Nov 2024DOI 10.17582/journal.pjz/20230908191620 
Research ArticleExpression of Aquaporin-1 and Endothelin-1 in Children with Congenital Hydronephrosis
Jinjian Ma, Zhaokang Wang, Hong Liu
The objective of this study was to analyze the expression of aquaporin-1 (AQP-1) and endothelin-1 (ET-1) in children with congenital hydronephrosis. A study group consisted of 52 children who were admitted to our hospital from August 2021 to August 2022 and di…
11 Nov 2024DOI 10.17582/journal.pjz/20230730043006- Research Article
Effect of Clopidogrel Combined with Atorvastatin on Serum Lipids, Inflammatory Factors and Cardiac Function Parameters in Patients with Angina Pectoris and Coronary Heart Disease
Jiaojiao Ma, Jialei Jiang, Lijun Shan
The objective of this study was to analyze the regulatory effect of Clopidogrel combined with Atorvastatin on the low-density lipoprotein cholesterol (LDL-C), triacylglycerol (TG), and total cholesterol (TC) in patients with angina pectoris and coronary heart…
11 Nov 2024DOI 10.17582/journal.pjz/20230816081639