Articles
3,477 open-access articles · page 37 of 174
Research ArticleExpression of Aquaporin-1 and Endothelin-1 in Children with Congenital Hydronephrosis
Jinjian Ma, Zhaokang Wang, Hong Liu
The objective of this study was to analyze the expression of aquaporin-1 (AQP-1) and endothelin-1 (ET-1) in children with congenital hydronephrosis. A study group consisted of 52 children who were admitted to our hospital from August 2021 to August 2022 and di…
11 Nov 2024DOI 10.17582/journal.pjz/20230730043006
Research ArticleEffect of Moringa oleifera Leaf Meal on Mineral Contents of Labeo rohita Fingerlings
Muhammad Zubair-ul-Hassan Arsalan, Syed Makhdoom Hussain, Basharat Ali, Bilal Ahmad, Muhammad Qurban, Adan Naeem et al.
Fish meal, a highly digestible source of protein in aqua feed, has not been readily available to fulfill the need for sustainable aquaculture production due to its limited supply and high price. So, the aim of this study was to develop more sustainable and eco…
11 Nov 2024DOI 10.17582/journal.pjz/20230413200442
Research ArticleCarvacrol Induces Doxorubicin-Resistant Breast Cancer Cell Apoptosis via Inhibition of the PI3K/Akt Pathway
Hu-Hu Chen, Jiao-han Zhou, Siat Yee Fong
Doxorubicin (Dox), a widely used chemotherapeutic agent for breast cancer, is often ineffective due to the development of Dox resistance, posing a significant challenge in cancer treatment. Carvacrol is a monoterpene phenol with diverse biological activities,…
11 Nov 2024DOI 10.17582/journal.pjz/20220421100442
Research ArticlePreparation and Characterization of Iron Oxide Nanoparticles for Effective Epirubicin Delivery to Drug Resistant Breast Cancer Cells
Sayra Tariq, Zeeshan Mutahir, Moazzam Ali
Chemoresistance is toughest of all challenges in the fight against cancer. The incorporated drugs are pumped out of the cells due to a number of reasons. However, if these drugs are attached to nanoparticles, they are likly to be retained by the cells for long…
11 Nov 2024DOI 10.17582/journal.pjz/20230227180246- Research Article
Protective Effect of Shengdi-Cogongrass Decoction on Patients with Blood Heat Psoriasis
Duo Yuan, Bin Shi, Yanhua Tu
Shengdi-cogongrass decoction (SCD) is a traditional Chinese medicine formula, mainly composed of raw Rehmannia glutinosa (RG) and lalang grass rhizome (LGR). However, little is known about the molecular pharmacological activity of Shengdi-cogongrass on blood h…
11 Nov 2024DOI 10.17582/journal.pjz/20231215095814 
Research ArticleEffect of Human Recombinant Activated Coagulation Factor VII (rFVIIa) on Total Bleeding Volume and Coagulation Function of Patients
Xiaolei Yan, Yabing Tang, Sainan Hu
The aim of this study was to analyze the effect of human recombinant activated coagulation factor VII (rFVIIa) on total bleeding volume and coagulation function of patients with postpartum hemorrhage (PPH). A total of 80 patients with PPH in Hunan Provincial M…
10 Nov 2024DOI 10.17582/journal.pjz/2023041107045
Research ArticleEffect of Hypertension on Blood Lithium Level and its Concentration to Dose Ratio in Manic Episode Patients
Dan Liao, Mingchao Li, Zijun Xiong, Qiuming Ji, Ying Xia, Bing Liu et al.
The objective of this study was to further explore the influence of hypertension on blood lithium levels and its concentration to dose ratio (C/D) in patients with manic episodes. A total of 112 patients with manic episodes from the Wuhan Wudong Hospital betwe…
10 Nov 2024DOI 10.17582/journal.pjz/20230728161028
Research ArticleEnhanced Antitumor and Anti-Metastasis Efficiency via Combined Treatment with Carvacrol and Doxorubicin
Hu-Hu Chen, Xin Li, Mohd Hijaz Mohd Sani, Siat Yee Fong
Recent research on treatment of triple-negative breast cancer (TNBC) has focused on drug combinations that can improve their anticancer properties while minimizing adverse effects. This study investigated the efficacy of combined treatment with doxorubicin (Do…
10 Nov 2024DOI 10.17582/journal.pjz/20211208031233
Research ArticleStudy on the Treatment of Experimental Dermatitis with Ginkgo biloba Leaf Extract and Quercetin
Minghui Xiao, Minjie Huang, Jie Dong, Deqian Wang
Allergic contact dermatitis (ACD), is a classic delayed allergic reaction mediated by cellular immunity. P815 degranulation model was established by stimulating P815 cells with C48/80 inducer to explore the effect and mechanism of quercetin on mast cell degran…
10 Nov 2024DOI 10.17582/journal.pjz/20220929090947
Research ArticleIdentification and Verification of Hub mRNA-miRNA-lncRNA Network on Psoriasis by Integrated Bioinformatics Analysis
Wen-Da Wang, Wei-Yue Gong, Bin Li, Shan-Shan Lei, Qing-Hua Wang
Psoriasis is an immune-mediated skin disease with a high incidence, it has been demonstrated that particular long non-coding RNAs (lncRNAs) are vital in psoriasis. However, their exact functions and regulatory mechanisms in psoriasis remain unclear. In this st…
10 Nov 2024DOI 10.17582/journal.pjz/20220310020325
Research ArticleCPEB3 Targets E-Cadherin mRNAs in a Post-Transcriptional Regulation Manner and Inhibits the Invasiveness of Ovarian Cancer Cells
Yanhua Zhang, Hui Li, Xinya Li, Yong Zhang, Rongqing Li, Chen Qing
CPEB3 (cytoplasmic polyadenylation element binding protein 3) is a key factor that controls poly A tail extension during translation, exhibiting a tumor suppressor effect in several kinds of tumors. However, its expression characteristics and functional role i…
10 Nov 2024DOI 10.17582/journal.pjz/20210829050829
Research ArticleAdvancement of KIF20B in the Process of Invasion and Metastasis of Colon Cancer Induced by EMT Through Gli1
Wenfeng Lin, Qiqi Zheng
The aim of this study was to determine the role of KIF20B in the metastasis of colon cancer cells. CCK-8 method and Transwell cell test were used to determine the proliferation, invasion, and migration of cells. Western blotting was used to determine the chang…
10 Nov 2024DOI 10.17582/journal.pjz/20230118070141- Research Article
Effect of Beauty and Freckle Removing Soup Combined with Reduced Glutathione on Oxidative Stress and Disease-Related Factors in Patients with Chloasma
Jing He
The objective of this study was to discuss the effect of Beauty and Freckle Removing Soup (BFRS) combined with reduced glutathione on oxidative stress (OS) and disease-related factors in patients with chloasma. Patients with chloasma were selected in West Anhu…
10 Nov 2024DOI 10.17582/journal.pjz/20230311050312 - Research Article
Effects of Ginsenoside Rg3 on HLA-DR, HLA-ABC and Cellular Immune Function in Patients with Tumor Radiotherapy
Xiang Lv, Sufang Zhang, Li Ling, Xian Wang, Ying Xia, Xiaoping Wang et al.
The objective of this study was to study the effect of Ginsenoside Rg3 on HLA-DR, HLA-ABC and cellular immune function in patients with tumor radiotherapy. From July 2017 to August 2018, 80 patients who were diagnosed as tumor and received radiotherapy were ra…
10 Nov 2024DOI 10.17582/journal.pjz/20230428190417 - Research Article
Predictive Study of Serum Matrix Metalloproteinase-8 in Combination with Human Chorionic Gonadotropin in Preterm Amniotic Cavity Infection
Yashu Lv, Yueyue Gao, Jinyi Wang, Yunchun Liu, Guiqing Jiao
The objective of this study was to investigate the predictive value of serum matrix metalloproteinase-8 (MMP-8) combined with human chorionic gonadotropin (hCG) for preterm amniotic cavity infection. The study included ninety patients with preterm labor admitt…
10 Nov 2024DOI 10.17582/journal.pjz/20230214050230 - Research Article
The Value of Procalcitonin Combined with C-Reactive Protein Assay in the Early Clinical Diagnosis of Bloodstream Infection
Cheng-Hong Chen, Ling-Xian Ding
This study aims to investigate the application value of procalcitonin (PCT) paired with C-reactive protein (CRP) in the early diagnosis of bloodstream infection. This study involved 298 patients with suspected bloodstream infections who were hospitalized in ou…
10 Nov 2024DOI 10.17582/journal.pjz/20221011021005 - Research Article
Analgesic Effect of Nalbuphine Combined with Sufentanil After Laparoscopic Hysterectomy
Zhenfeng Cai, Xingli Jiang, Xintao Dai, Pinglei Wu
The objective of this study was to examine the effect of PCIA analgesia after laparoscopic hysterectomy (LH) with Nalbupine combined with Sufentanil on Visual Analogue Scale/Score (VAS), Ramnsay sedation score, serum prostaglandin E2 (PGE2), 5-hydroxytryptamin…
10 Nov 2024DOI 10.17582/journal.pjz/20230331210308 - Research Article
Effect of Consistency of Diet on Swallowing and Blood Biochemical Components of Patients with Dysphagia After Brain Injury Surgery
Shuang Jin, Lishu Sun, He Wang, Yang Li
The objective of this study was to explore the effect of food consistency diet on different indicators and scales in patients with dysphagia after brain injury surgery. Patients (104) with traumatic brain injury who underwent surgical treatment were selected i…
10 Nov 2024DOI 10.17582/journal.pjz/20230315050318 - Research Article
Long Term Effects of SSRI Antidepressants on Levels of Different Serum Growth Factors in Patients with Depression
En Zhang, Ming Zhu, Wenli Zhu, Wei Xiong, Zhongfei Huang, Xin Qiao et al.
The objective of this study was to investigate the effect of long-term use of SSRI (selective serotonin reuptake inhibitors) antidepressants on serum nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF), vascular endothelial growth fac…
10 Nov 2024DOI 10.17582/journal.pjz/20230213200208 
Research ArticleFactors Affecting the Absorption of Exosomes by Sertoli Cells
Ma Hong, Fu Bo, Wang Liang, Wang Fang, Guo Zhenhua, Liu Di
Exosomes play an important role in the signal transmission process of Sertoli (ST) cells. However, what factors affect the ability of ST cells to take up exosomes remains unclear. To investigate the influences of time, temperature, cytochalasin D (Cyt D), and…
10 Nov 2024DOI 10.17582/journal.pjz/20220727010714