Search for Curcumin

Bax and CD68 Expression in Response to Liver Injury Induced by Acetaminophen: The Hepatoprotective Role of Thymoquinone and Curcumin

Laila M. Fadda¹, Nouf M. Al-Rasheed¹, Iman H. Hasan¹, Hanaa M. Ali^2,3*, Nawal M. Al-Rasheed^1,4, Musaed Al-Fayez⁵, Aly M. Ahmed⁵, Nada Almutlaq¹, Nehal Qasem¹ and Reem Khalaf¹

Therapeutic Effects of Curcuma longa against Rotenone-Induced Gross Motor Skill Deficits in Rats

Syeda Madiha, Zehra Batool, Saiqa Tabassum, Laraib Liaquat, Sadia Sadir, Tahira Perveen and Saida Haider*

...d the protective role of curcumin against rotenone-induced motor deficits, biochemical and neurochemical alterations. Rotenone was injected subcutaneously at the dose of 1.5 mg/kg for 8 days. Supplementation of curcumin (100 mg/kg/day, p.o.) was started before 15 days of rotenone injection. The effects of curcumin pre-treatment were evaluated by different motor behavioral parameters (pole ...

Exploring the Potential of Honey and Curcumin as Antidepressent

Muhammad Naveed Sheas¹, Haris Rasool², Muhammad Nouman Rafique², Muhammad Rizwan Tariq^1*, Abid Muhammad¹, Khubaib Ali¹

... of wellbeing. Honey and curcumin, traditional folk medicines, are thought to steadfast the defense mechanisms of body against oxidative stress which is a key factor in elevating depression. This study is designed to reveal the efficacy of honey and curcumin against depression in rat model. 24 male wister rats were randomly divided into 4 groups. After the trial, blood biochemistry was done in which antioxidant enzymes like ...

Turmeric Plays Protective Role against Paraben Induced Hepatic and Renal Lesions in Albino Mice

Chaman Ara^1*, Asmatullah¹, Zainab Riaz¹, Memoona¹, Asma Chaudhary², Shagufta Andleeb²

Effects of Curcumin on Growth and Liver-protection in Common Carp, Cyprinus carpio

Yuanyuan Zhang¹*, Liping Song¹, Hui Guo², Jun Wu¹, Xiaoli Wang¹ and Fangbin Yao¹

...d antioxidant effects of curcumin against carbon tetrachloride (CCl₄)-induced liver injury in common carp Cyprinus carpio. A 10-week feeding trial was carried out. A basal feed was supplemented with 0 (control), 30, 60, 120 and 240 mg/kg curcumin to formulate five experimental feeds. At the end of the feeding trial, the growth performance was determined. Subsequently, CCl₄ was used for the model ...

In-vitro management of Potato Leafroll Virus (PLRV) by using active material of different natural products

Tahsin S. Shoala1, Ahmed K. El-Attar2, Ahmed I. Abd El Maksoud3

...iv>potato plantlets with curcumin showed that PLRV present in concentrations 2ng/ ml in the MS

media but treated potato plants with concentration 4ng and8 ng/ml in the MS media were

negative to PLRV. Moreover, treated potato plants with Rosmarinic acid and Glycyrrhizic

acid showed that the presence of PLRV in all concentrations (2ng, 4ng, 8ng/ ml in the MS

media).

Conclusion: In-Vitro application of G...

Insilico Screening of Bioactive Phytochemicals against Spike Protein of COVID-19

Muhammad Hamza Tariq¹, Mahjabeen Akram² and Yasir Sharif³*

Comparative Study of Curcumin and Garlic Extracts as Antioxidants in Growing Rabbit Diets on Productive Performance and Antioxidant Status

A. Samy1*, H.M.A. Hassan1, Fatma T.F. Abd-El Ghany2, Shama H. Morsy2

...d to evaluate how adding curcumin and garlic extracts to the diet of growing rabbits affected productive performance, carcass characteristics and antioxidant status. Sixty growing rabbits (APRI) were divided into five groups of 12 rabbits each at the age of six weeks. Five diets containing the same proportions of all nutrients were made. The first control diet (without any additives); curcumin (CE) or garlic extract (GE) at ...

Effects of Moringa oleifera, Curcumin, and Green Tea Extracts on Histopathological Changes in Mesenteric Lymph Nodes and Spleen of Albino Rats with Benzene-Induced Leukemia

Ahmed Alazzouni¹, Ashraf Al-Brakati^2,*, Sherif Rabie¹, Mohamed Gabry¹ and Basmaa Hassan¹

...ect of Moringa oleifera, curcumin, and green tea extracts against benzene chromasolv-induced leukaemia in rats and their ability to alleviate the histopathological alterations in the mesenteric lymph nodes (MLNs) and spleen. In this study 70 rats were divided into seven groups as follow: control, benzene (0.2 ml twice/week), Moringa oleifera (100 mg/kg), curcumin (300 mg/kg), green tea (350 mg/kg), combined green tea and

Evaluation of a Herbal Muco-adhesive Gel for Treatment of Oral Submucous Fibrosis in Wistar Rats

Iqra Ejaz¹, Saima Chaudhry² and Sarah Ghafoor¹*

... novel combination of 1% curcumin and licorice, in an animal model of oral submucous fibrosis (OSMF), as a possible treatment modality. Animal model of OSMF was created by injecting an anti-cancer drug Bleomycin (1mg/mL) into buccal mucosa of animals daily for 8 weeks. The 24 male Wistar rats were equally divided into two groups; six rats (group 1A) were injected with normal saline (control group) while 18 rats (groups 1B, 2A and 2B, experimental groups) were ...

Synthesis, Characterization and Investigation of the Anticoccidial Activity of New formulation Curcumin - Olive Oil Nano-Composite

Reem M. Ramadan1, Fady Sayed Youssef2, Gehad Genidy Mohamed3, Sameh Hamed Ismail4, M.M. El-Bahy1, Shimaa Abdel-Radi1*

...p>New formulation of nanocurcumin (curcumin-olive oil nano-composite; C-Oo.Nc) was produced and characterized in the present study. The produced nanoparticles are spherical with 63 nm zeta size and high stability in the aqueous media. The coccidiocidal efficacy of the C-Oo.Nc was evaluated versus five chicken Eimeria species oocysts. The immature oocysts were exposed to 5, 10, 20, and 40 ppm, each for 1, 3, 6, 9, 12, 24, and...

Effect of Sericin and Curcumin Mixture on Hematological Alternations Associated with Carrageenan Induced Paw Edema in Mice

Sehrish Ashraaf¹, Hafiz Muhammad Tahir¹*, Chand Raza¹, Ayesha Muzamil¹, Farman Ahmad Chaudhary², Muhammad Summer¹ and Aamir Ali¹

...he effect of sericin and curcumin either alone or together on the reversal of hematological changes induced by carrageenan in the mice model. Mice were induced edema via λ-carrageenan (50µl/ mice) and different concentrations of sericin (0.03 mg/ml, 0.06 mg/ml and 0.09 mg/ml) and curcumin (1%, 2%, and 3%) were administered to the respective groups, then blood was collected for hematological analysis to observe t...

Effect of Sericin and Curcumin Mixture on Hematological Alternations Associated with Carrageenan Induced Paw Edema in Mice

Sehrish Ashraaf¹, Hafiz Muhammad Tahir¹*, Chand Raza¹, Ayesha Muzamil¹, Farman Ahmad Chaudhary², Muhammad Summer¹ and Aamir Ali¹

An Early Screening of Turmeric as an Antibiotic Growth Promoter Replacement and its Effects on the Reproductive Organs of Mojosari Ducks

Widiastuti Ardiansyah1,3, Osfar Sjofjan2*, Eko Widodo2, Suyadi Suyadi2, Danung Nur Adli2

... increasing the level of curcumin produced a linear increase in the number of bioactive compounds and the reproductive organs of Mojosari ducks.

Keywords | Bioactive compound, Follicle, Mojosari Duck, Reproductive Organ, Turmeric

...

Biology, Histopathology and Treatment Evaluation Against Cryptosporidium meleagirids on Infected Quails

Khitam J. Yahya*, Mohammed T. S. Al-Zubaidi

...ptosporidial efficacy of curcumin in experimentally infected quails compared with that of paromomycin. This study carries out from September 2022 to January 2023 in Baghdad city, Iraq. Oocysts were isolated from naturally infected quails identified as Cryptosporidium meleagridis and used as a strain in experimental infection, about fifty birds were divided into five groups (G1: control negative group (con-), G2: control positive group (con+), G3: infected and ...

Curcumin Phytosome as an Anti- inflammatory and Hypolipidemic in Nano-Silicon Treated Female Rats

Ghusoon Hasan Jadaan1*, Khalisa K. Khudair2

... SiO2NPs and 100mg/kg of curcumin phytosome, and T3: was administered oral 100 mg/kg of curcumin phytosome. Blood samples were collected from anesthetized rats through cardiac puncture by terminating the experiment. The samples were analyzed for total cholesterol (TC), triacylglycerols (TAG), high-density lipoprotein (HDL)-c, low-density lipoprotein (LDL)-c, very low-density lipoprotein (VLDL)-c concentrations, tumor necros...

Leverage of Nano-Curcumin Phytosome in Nano-Silicon Dioxide Treated Female Rats

Ghusoon Hasan Jadaan1*, Khalisa K. Khudair2

The Neuroprotective Effect of Curcumin Cumin Against Oxidative Stress Induced by Acrylamide in Male Rats

Estabraq Hayder Khayoon, Ammar Ahmed Abdulwahid*

Antifertility Effects of Curcumin on Sperm Quality, Morphology of Testicular, and Seminal Vesicle in Rats (Rattus norvegicus)

Hilwah Nora^1,2, Rajuddin²*, Hafizuddin³, Rachmad Suhanda⁴, M. Fathurrahman⁵

...eral studies report that curcumin has antifertility effects and has the potential to regulate male fertility (contraception). However, determining the initial dose is preliminary studies based on spermatozoa quality parameters, morphology, and morphometry of testes and seminal vesicles that have never been reported. The main objective of this research is to examine the effects of curcumin on several aspects of reproduction a...

Insights into Curcumin-Selenium Nanoparticles in Modulating Hormonal Levels and Promoting PTEN Gene Expression in Doxorubicin Treated Rats

Rawya Sh. Mohammed*, Baraa N. Al-Okaily

...ve impact of synthesized curcumin selenium nanoparticles (CurSeNPs), using a hydroalcoholic extract of Curcuma longa rhizomes, in reducing disruption to hormonal profiles, redox homeostasis, inflammatory parameters, and ovarian tissue PTEN gene expressions in rats treated with doxorubicin. CurSeNPs were synthesized using sodium hydrogen selenite and a hydroalcoholic extract derived from Curcuma longa. The in vivo study utilized thirty-two mature female rats di...

Alterations of VEGF Expression and Ovarian Follicles in Doxorubicin Treated Rats: Role of Curcumin Selenium Nanoparticles

Rawya Shakir Mohammed*, Baraa Najim Al-Okaily

...e effects of synthesized curcumin-selenium nanoparticles (CurSeNPs) by combining sodium hydrogen selenite with a hydroalcoholic extract obtained from Curcuma longa rhizomes in alleviating the disturbance of vascular endothelial growth factor (VEGF) mRNA expression, histomorphometric and histological alterations of ovaries in healthy rats that administered doxorubicin.Thirty-two fully grown female rats were randomly divided into four equal groups and were treat...

Deviation in the Metabolite Activity and Decreases in Escherichia coli Load in Anopheles Mosquitoes After Feeding with Blood Meal Treated with Nanocurcumin

Sura Saad Hamada Alkhuzaie

...s after feeding with nanocurcumin-treated blood meal (NBM). The study included the use of 216 female mosquitoes divided randomly into six replicates for each group. The groups were a 6hr-ealier provision of NBM before E. coli exposure, the 6E group, in which NBM was provided to mosquitoes 6hrs before bacterial exposure. There was a group in which both E. coli exposure (ECE) and NBM were provided at the same time, the 0T group. In addition, there was a 6hr-late...

Curcuma xanthorrhiza Diluent’s Effect on the Freezing and Thawing of Thin-Tailed Ram Sperm

Sigit Bintara¹*, Diah Tri Widayati¹ and Pradita Iustitia Sitaresmi²

...dant properties, such as curcumin, tumerol, and xanthorrhizol, which can be used for ram semen cryopreservation. This study examined the effects of C. xanthorrhiza extract on semen parameters after the freeze-thaw treatment in frozen semen processing. Four healthy and mature ram was conducted to collect the fresh semen in this research. Each donor’s ejaculate will be separated into five wells and diluted in an egg yolk citrate (2.9% (v/v)) extender conta...

Effects of Gamma-Irradiated Aqueous Extract of Turmeric on Doxorubicin Induced Cardio-Nephrotoxicity in Male Rats

A.M. Abdul Azeem¹, A.N. El shahat¹, Mohamed H.M. Abd El Megid² and Amal A. Mansour¹*

...antioxidant activity and curcumin content of turmeric powder. Also, this study was aimed to investigate the influences of aqueous extract gamma-irradiated turmeric on doxorubicin (DOX)‑induced cardio-nephrotoxicity in male rats. The result indicates that the total phenolic content, antioxidant activity and curcumin content of turmeric powder were significantly increased by γ-irradiation. The results of biological stu...

Effect of Adding Different Levels of Curcumin Powder to the Diet on some Reproductive, Fertility and Hatchability Performance of Broiler Breeders

Basim Mandeel Malik Al-Sharifi*, Emad Abdulgabber Ali

... 250, 300, and 350 mg of curcumin powder per kg of feed for the males, and the same additives were used for the females. The results indicated that treatment T4 showed significant (P≤0.05) superiority in reproductive traits, specifically ejaculate volume and mass, and individual sperm motility, compared with treatment T1, the control. Treatment T4 was also significantly (P≤0.05) superior to treatments T1, T2, and T3 in sperm concentration rate. Treatment...

In Vitro Evaluation of Aromatic Galangal Extract as a Feed Additive on Pathogenic Bacteria in the Super Kampong Chicken Digestive Tract

Wahyu Widodo¹*, Adi Sutanto^1, Imbang Dwi Rahayu¹, Ivar Zekker², Bayu Agung Prahardika³,

Apriliana Devi Anggraini¹, Trisakti Handayani¹ and Yuanara Augusta Rahmat Adikara⁴

...elatively high amount of curcumin compounds that can be used as a feed additive. This curcumin can inhibit and kill pathogenic bacteria in the digestive tract of Super Kampong chickens. The purpose of this study was to evaluate aromatic galangal (Kaempferia galanga) extract. Aromatic galangals from Lumajang Regency, East Java Indonesia – a high curcumin content of 39.5 µ...