Amreen Zahra1, Mushtaq A. Saleem1*, Hasnain Javed2, Muhammad Azmat Ullah Khan3, Muhammad Naveed1 and Abdul Rauf Shakoori4
...t study was to study the hypervirulence of SNPs in the Gag-Pol proteins by molecular modeling approaches. Mutational analysis in our study revealed S61A, S61M, S61Y, S61G, S61Q and M90L as the most hypervirulent mutations. This induces a selection pressure and a rate of increased virulency on Gag-Pol cleavage sites. These results significantly highlight the fact that the identified SNPs possibly contribute towards a positive selection pressure contributing to ...
Enas M. Hefzy1*; Reda M. Taha2; Safaa Abd El Salam2; Abdelrhman Abdelmoktader1; Mahmoud A.F. Khalil3
...rial that gives hvKp its hypervirulence phenotype. Although the vast majority of
hvKp isolates are antibiotic-susceptible, the incidence of virulent as well as resistant isolates,
such as carbapenem-resistant hvKp isolates, is continuously growing. Multidrug resistance
(MDR) and increased virulence of these strains may be the cause of the subsequent clinical
crisis. This study aimed to review and analyse the epid...
