Songhao Zhang1, Yiwen Gong1, Jian Xu1, Mou Hu2, Peng Xu3 and Yanliang Jiang1,2,4,*
... four pathways including melanin biosynthesis, TGF-beta signaling, Wnt signaling and MAPK signaling pathways. We obtained candidate genes that may affect the morphological characteristics of purse red carp resulted from the long history of domestication, including TYRP1b, PMELa, KITa, BMP8a, ACVR2aa, TGFB1a, TGFB3, TGFBR2. Understanding the molecular mechanisms underlying the biological characteristics of...
Moazam Ali1, Wajid Ali2, Ayhan Ceyhan2 and Zeeshan Ahmad Bhutta3*
Pigmentation Genome Influence in Animals and Human Interventions in its Course of Action
...d process to produce the melanin from melanocytes. Melanin amount, size, shape, and distribution control the color pigmentation of fiber, coat, and hairs in animals. Melanin production in an intricate course is under the control of Melanocortin 1 Receptor, alpha Melanocyte stimulating hormone and Agouti signaling gene. In most animals, three different alleles encoding melanocyte-stimulatin...
Abdullah Sheikh1,*, Faisal Almathen1,2 and Hairul Islam Mohamed Ibrahim3,4
...cts as a precursor for eumelanin or pheomelanin. There have been many studies that reported variations in this gene associate with the coat color of the animal. This is the first study of TYR gene expression analysis from various dromedary or Arabian camel (Camelus dromedarius) phenotypes from Saudi Arabia. The four camel groups included were white, diluted (light brown, creamy and fawn), black and dark brown r...
Hadia Gul1, Abdul Haleem Shah1, Ricardo Harripaul2, Anna Mikhailov2, Ejaz Ullah Khan3, Wasim Shah3, Nisar Ahmad3, John B Vincent2,4 and Muzammil Ahmad Khan3*
...rs due to defects in the melanin synthesis pathway. OCA is characterized by hypopigmentation of hair, dermis, and ocular tissue. The clinical consequences of OCA includes whitish skin, whitish to golden hair and photophobia. Genetic studies have so far reported seven non-syndromic OCA genes, among which Pakistani OCA families mostly segregate TYR and OCA2 gene mutations. In the present study we aimed to investigate the genetic factor of OCA in a consanguineous...
Farrukh Avais1, Anser Ali1, Hamza Javed2, Muhammad Saleem3, Tehreem Tahir4,
Muhammad Rafiq5,*
...roblems. Thus to achieve melanin inhibition, inhibition of
tyrosinase might be an effective approach. To this end we prepared methanolic (MeOH)
extracts from leaves and roots of Garlic Allium sativum (AS) and Peppermint Mentha
piperita (MP), which were further processed for 1:1 fractional distillation to prepare
methanolic n-hexane (MeOH_n-Hx), methanolic ethyl acetate (MeOH_EA) and
methanolic chlorof...
