Muhammad Mushtaq, Umer Sadique, Naila Chand, Iftikhar Ahmed, Said Sajjad Ali Shah, Ijaz Ahmad, Imran Ullah and Muqadar Shah
...caused by high fat diet, obesity and diabetes.Hypolipidemic and hypoglycemic effect of water based infusion of Withania somnifera was investigated in broiler chicks. One hundred and twenty (120) day-old broiler’s chicks were alienated into four treatment groups namely WST-0, WST-I, WST-II and WST-III with three replication. Group WST-0 was kept as a control, while WST-I, WST-II and WST-III were treated with W. somnifera water based infusion @ 10, 20 and ...
Farah Ashfaq* and Tasnim Farasat
...and metabolic markers of obesity in young Pakistani subjects.
...
Muhammad Saqlain1, Humaira Kalsoom1, Muhammad Fiaz1,2, Abid Mahmood1, Rizwan Aziz Qazi4 ,Waseem Safdar5, Pakeeza Arzoo Shaiq1,Bernard M.Y. Cheung3 and Ghazala Kaukab Raja1,*
... for insulin resistance, obesity, diabetes, and metabolic syndrome (MetS). In this study the association of Ala54Thr polymorphism with MetS and its risk components was studied in a local Pakistani population. MetS subjects and controls were recruited from out-patient departments of Pakistani hospitals. Ala54Thr genotyping of 200 MetS patients and 200 healthy controls was performed using a PCR-RFLP. Genotype and allele frequencies were calculated and computed f...
Mian Sajjad Ahmad1, Somia Iqtadar1, Sami Ullah Mumtaz1*, Zafar Niaz1, Iqra Waheed2 and Sajid Abaidullah1
...ould be taken to control obesity. ...
Ambreen Asghar, Tasleem Akhtar, Nadeem Sheikh*
...etabolic disturbance and obesity. Despite the genetic regulation of metabolic responses, a close relationship between high energy food-intake and increased body-weight has been reported to support several pathologies in the metabolic and immune system. Present work was designed to evaluate the variations in serum protein level induced by fat rich diet. For this purpose, two groups of Wister rats were fed with diets carrying difference in percentage of fats. Pr...
Rana Khurram Aftab1*, Farhat Ijaz2, Samia Jawed3
...The relationship between obesity and hypertension has long been recognized. Overweight and obesity are disorders of balance of energy affecting people of various ethnic groups, age and socio–economic statuses. It has been found that obesity is closely associated and correlated with hypertension. Preventive strategies for obesity may offer a cost-ef...
Farhat Ijaz1, Rana Khurram Aftab2*, Samia Jawed3
...tion of TNF-α with obesity induced IR and T2DM is unclear as results obtained from different studies are very controversial.
Objective: This study was designed to compare TNF-α levels and insulin resistance in obese and non-obese type 2 diabetics.
Methodology: A cross sectional comparative study was conducted in diabetic clinic of Mayo Hospital, Lahore. We determined and compared TNF-α levels and insulin ...
Muhammad Younus1*, Sabah Usman2 and Samia Jawed3
Iqra Arooj1,* and Shahida Hasnain2
...isk factors are smoking, obesity, diabetes, family history, high blood pressure etc. Previous genome wide association studies have identified association of large number of loci with risk of CHD in different populations. The purpose of this study was to determine the association of 6q25.1/rs6922269 and 9p21.3/rs1333049 loci with risk of CHD in a population of Punjab province of Pakistan. A total of 645 subjects were included in this study of which 435 were pat...
Shabana*, Saleem Ullah Shahid and Shahida Hasnain
...for HDL, which is low in obesity. The anthropometric traits were significantly different between dyslipidemic obese subjects and nondyslipidemic non obese subjects. In conclusion, obesity is accompanied by a dyslipidemic profile and increased weight and/or BMI. The progression of clinical forms of obesity can be assessed by the strong predicting indices, including weight, BMI, low HDL and ...
Mian Azhar Ahmad1†*, Nawab Mohammad Khan2, Asmatullah3
Anatomical variations of hepatobiliary triangle in patients operated laparoscopically for gallbladder diseases from Lahore and Sahiwal
... acute cholecystitis and obesity were subjected to Laparoscopic cholecystectomy. Patients’ age was between 18-70 years, gender ratio was 1:3.5 with female dominance, mean operative time 99.6 minutes and patients remained admitted for 1–3days. The procedure was performed successfully in 91% of the cases. In 09% cases, a conversion to standard open cholecystectomy was necessary; the most common cause was unclear anatomy. Laparoscopic cholecystectomy...
Syeda Ain-ul-Batool1, Sadia1, Kathrin Blasius2,3,4, Angela Kaindl2,3,4 and Ghazanfar Ali1,*
...strophy, eyes exotropia, obesity, polydactyly, hypogonadism, and renal abnormalities. Few additional features of BBS also include delayed motor development, clumsiness, anosomia, ataxia, hypodontia, hearing impairment, hirschsprung disease, cardiovascular and liver disorders. So far 21 genes are reported that cause BBS (BBS1-BBS21). A consanguineous family having clinical symptoms of BBS9 is described in current study. Mutation was detected in BBS9 on chromoso...
Hong Zhang1, Shu-Fen Han2, Jing Wang1, Shao-Kang Wang1, Gui-Ju Sun1 and Cheng-Kai Zhai1, *
...cholesterol diet-induced obesity and lipid accumulation in rats and the possible molecular mechanisms, 40 male Sprague-Dawley rats were randomly assigned to four different diets, including reference chow diet (RCD), high fat and cholesterol diet (HFCD), city diet (CD) and compound whole-grain diet (CWD). Serum lipid profiles and glucose level were examined after 8 weeks. The molecular mechanisms underlined the effects of CWD on lipid metabolism were investigat...
Rabia Khalid1, Saleema Bashir Shams1, Bibi Nazia Murtaza1,*, Gaitee Joshua1, Saira Mushtaq1, Hassan Al-Talhi2 and Abdulaziz Al-Amri2
...employees, prevalence of obesity was 67.53% and in general population it was 57.1%. The mean values of body mass index (BMI) for bank employees and control population was 24.10± 0.5 kg/m2 and 20.43±1.0 kg/m2, respectively. Analysis of the components of metabolic syndrome demonstrate an abnormal level of low density lipoproteins (LDL) 24.4% and 17.5%, total cholesterol 15% and 7.8%, triglycerides 17.35% and 8.8%, fasting bloo...
Mehwish Saleem Khan
Evaluation of Changes in Zinc Levels in Patients Suffering from Cancer
.... Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation and environmental pollutants. In this study zinc level in serum of cancer patients was observed. For this purpose, the blood of 50 cancer patients was taken from MAYO HOSPITAL Lahore. The patients are suffering from different type of cancers such as, breast cancer, lung cancer, uterus ...
Sara Sultan Alomran1, Muhammad Nasir Khan Khattak1,2, Amir Ali Khan1,2*, Sallam Hasan Abdallah2, Abeer Maher Fayyad1 and Khalid Bajou1,2
...greater understanding of obesity and subsequent treatment. In the current study, we assessed the effects of miR-22-3p, a non-coding RNA, on adipocyte differentiation from telomerase-transformed Mesenchymal Stromal Cells (iMSC3). The transfection of iMSC3 with miR-22-3p suppressed adipocyte differentiation as evident by reduction in lipid content and number of lipid droplets. While AKT3 is reported to be a target of miR-22-3p, our study indicated otherwise. Mor...
Hye-myoung, Jang 1,3, Ju-Hyeun, Kim3, Garam Park1, Yoon Dong Choi4, Sun-Eui Kim1,5, Gwang Joo Jeon1,2*
... Under the hypothesis of obesity inducing potential dementia, mice were fed with high-fat energy diet to gain excessive weight. The experimental groups in this study are 1) high-fat diet fed only (control) and 2) high-fat diet fed with AE added (AE group). After the experiment was terminated, they were slaughtered and brains were obtained. Throughout the experiment, measured were changes of body weight, blood chemical compositions, Aβ and τ-protein ex...
Emtenan M. Hanafi1*, Fouad M. Tawfeek2, Walid S. El Nattat1, Moetazza M. Alshafei3, Seham S. Kassem3, Kawkab A. Ahmed4, Enas N. Danial5, Hagar Elbakry3, Hoda S. El-Sayed2
Aysam Fayed1, Mohga A Ibrahem2, Soha A. Hassan3, Mohammed Abdalla Hussein4*, Tamer Roshdy1
...>The correlation between obesity and metabolic disorders like Type 2 diabetes, cardiovascular disease, and several types of cancer has made obesity a challenge for world health. The current study’s objective was to assess the antioxidant capacity of cranberry extract in high-fat diet-induced obesity. For eight weeks, 36 white albino rats weighing 197±10 g were selected at rand...
Amber Khalid1*, Farah Ashfaq1, Shahzadi Farah1, Amna Akbar1, Farkhanda Manzoor1, Muhammad Babar Khawar2, Saira Riaz3 and Safina Ashfaq3
...f the children Pediatric obesity has reached to epidemic proportions in Pakistan. Overweight children usually become overweight adults which ultimately cause serious ailments including type 2 diabetes, renal diseases and hypertension in later age due to alteration of different serological parameters. In conclusion weight is associated with biochemical parameters. Any alteration in these parameters may cause health issues. Effective pediatric interventions are ...
Mian Shamas Murtaza1,*, Aysha Sameen2, Saima Rafique3, Muhammad Shahbaz1,*, Nabeela Gulzar4, Mian Anjum Murtaza5, Umar Farooq1 and Iram Hafiz6
...eases like hypertension, obesity, cardiovascular diseases etc. Inulin is a food ingredient that belongs to a class of carbohydrates known as fructans with degree of polymerization range from 2-70. Resistant starch is obtained by chemical and enzymatic treatment of starch to increase its properties. These have functional and health-promoting properties as they reduce caloric value, add dietary fiber and endorse prebiotic effects. These are frequently used in in...
MUHAMMAD MUNEEB SOHAIL1, FATIMA AMEER2, GUR CHARN SINGH2, MUHAMMAD ZAID1*
...d classical indicator of obesity, other indicators like A Body Shape Index (ABSI) and Body Roundness Index (BRI), also proved significant in assessing the type and severity of dyslipidemia. Different lipoprotein fractions behaved differently with anthropometric parameters. Relationship of lipoprotein fractions with gender, ethnicity and occupation was also studied. Our study includes 79% of dyslipidemic and 21% of non-dyslipidemic patients. Males were more inc...
SYED ALI RAZA1, MUHAMMAD WASEEM MUMTAZ2*, AYOUB RASHID CH1, ABDUL WAHEED1, JAMES WILLIAM3 & MUHAMMAD ARSHAD1
....45%). The in-vitro anti-obesity attribute of extracts was assessed by measuring the inhibition of enzymatic activity of pancreatic lipase. The 60% ethanolic leaf extract exhibited maximum pancreatic lipase inhibition of 54.55 ± 0.72% but lower than standard drug orlistat (66.65 ± 0.68%). Findings explored the hidden antioxidant and pancreatic lipase inhibitory potential of Conocarpus lancifolius that may be exploited for naturopathic trea...
SAIMA SHARIF*, NIMRA PERVEEN, SHAGUFTA NAZ, TASNIM FARASAT, FARKHANDA MANZOOR,
ASMA ABDUL-LATIF & FARZANA RASHID
...etary calcium intake and obesity suggesting that an
increase in calcium intake can decrease the chances of obesity
incidence.
...
Shudong Liu1,2, Shuai Wang1,2, Haoran Cui1 and Genyuan Chen1,2*
...rentiation, diet-induced obesity, and nervous system development. The genomic regions identified in this study provided a start-up point for contribute to similar studies and can facilitate the potential utilization of genes involved in etiology of Chinese Merino sheep alopecia in the future....
SAIMA SHARIF, SHAGUFTA NAZ, FARKHANDA MANZOOR, AYESHA NOOR & ZAHRA JAMIL
...ip of lung function with obesity in healthy subject. The study was carried out in young females of Lahore College for Women University, Lahore from January 2017 to June 2017. During this period a total of 180 females were enrolled. Anthropometric measurements and the BMI of subjects were measured according to standard protocol after taking written consents. On the basis of body mass Index (BMI) subjects were divided into three groups normal weight (n=80), over...
Yanfei Cai1, Jiahong Feng1 and Wanlong Zhu1,2,3*
...iseases, but research on obesity in the past few decades has obtained only limited results. The discovery of the metabolic healthy obesity phenomenon brings a new direction for research of obesity problem, but the lack of an animal of metabolic healthy obesity limits its study. Tupaia belangeri is a new type of experimental animal emerging in recent year...
Farhatul-Ain Arshad1, Asia Bibi1*, Amna Mushtaq1, Rubaida Mehmood2 and Nahid Kausar1
...together, we showed that obesity is not an exclusive factor involved in the development of PCOS. The occurrence and prevalence of PCOS are attributed to multiple alternative factors which warrant future studies comprising of larger cohorts and at the national levels....
