Chaman Ara1*, Asmatullah1, Sehrish Kanwa1, Asma Chaudhary2, Ayesha Siddiqua1
..., a broad spectrum fluoroquinolone antibiotic of third generation, is widely used to treat respiratory and genitourinary infections. Keeping in view the controversy about its toxicity, current study was conducted to assess the levofloxacin induced hepatotoxicity, nephrotoxicity and its likely noxious effects on spermatogenesis in mammals. Forty mice, randomly categorized into four groups (N=10) were administered orally with different concentrations of levoflox...
Mumtazur Rahman1, Farhan Anwar Khan1,*,Umar Sadique1, Ijaz Ahmad1, Shakoor Ahmad1, Faisal Ahmad1,2, Hayatullah Khan1,3, Muhammad Saeed1, Faiz Ur Rehman1, Ibrar Hussain1, M. Faraz Khan1, M. Izhar ul Haque1 and Hanif-ur-Rehman1,3
...t commercially available quinolones in Pakistan by broth microdilution method. Quinolones including moxifloxacin, levofloxacin, ciprofloxacin, and enrofloxacin were selected for in vitro susceptibility of Mccp Pakistan strain. The concentration for each drug was measured distantly depending on high concentration available in the market and was then used in various concentrations ranges from higher to lower i.e. moxifl...
Sana Ilyas1, Muhammad Hidayat Rasool1,*, Muhammad Javed Arshed2, Muhammad Usman Qamar1 and Bilal Aslam1
...athway inhibitors, fluoroquinolones, and aminoglycosides. This study investigates the high prevalence of ESBL producing E. coli in chicken, farmworkers, and water that is alarming and could lead to serious threats to both livestock and public health.
...
Muhammad Noman Koondhar1, Asghar Ali Kamboh1,*, Muhammad Ammar Khan2, Riaz Ahmed Leghari3 and Parkash Dewani4
...ine (73.9 to 78.6%), and quinolones (59.6 to 63.1%). While lowest resistance level was observed against the antibiotics of cephalosporin group (32.1 to 52.6%). Among 13 isolates of S. Pullorum, a highest number (10 isolates) showed resistance against neomycin, kanamycin and tetracycline. A total of 76.9% (10/13) isolates were recorded as multidrug resistant (MDR) resistant. Maximum number of S. Gallina...
Aqsa Shahid1, Saima Muzammil1, Farhan Rasheed2,Bilal Aslam1, Muhammad Akhtar Ali3, Syed Zohaib Haider4, Masroor Ellahi Babar4, Muhammad Saeed1, Umair Waqas1 and Mohsin Khurshid1,*
...inoglycosides, and fluoroquinolones whereas colistin and tigecycline were the most active antimicrobial agents against A. baumannii as none of the isolates was found resistant to these two drugs. Moreover, the armA was found in 25% (n=37) of A. baumannii isolates which showed a high level of resistance to aminoglycosides i.e., amikacin; ≥256µg/ml (Breakpoints; ≥64µg/ml) and gentamicin; ≥MIC 64µg/ml (Breakpoints; ...
Prima Mei Widiyanti1*, Mirnawati B Sudarwanto2, Etih Sudarnika2, Raphaella Widiastuti1
...acin is one of the fluoroquinolone antibiotics used for therapy in animals. The presence of enrofloxacin antibiotic residue in milk could affect product quality and human health. This study aimed to determine the heating effect of enrofloxacin antibiotic in milk. The milk samples spiked with enrofloxacin antibiotic were submitted to thermal treatments. The milk samples were analyzed using high performance liquid chromatography (HPLC) method. This study showed ...
Mohamed S. Hussein1*, Hanan A. Fahmy2, Ashraf A. Abd El Tawab3
...typic characteristics of quinolones and fluoroquinolones resistance in Escherichia coli recovered from apparently healthy broiler chickens in Egypt. A total of 150 cloacal swabs collected from broiler chickens from farms and bird markets were subjected to bacteriological and biochemical examination. The results revealed that 92% (138/150) of samples were found positive for E. coli. The antimicrobial susceptibility testing of...
Mona M. Osman1, Kamelia M. Osman2, Manal Abu Elmakarem Mohamed1, Mahmoud E. Hashad2, Jeeser Alves Almeida3, Alaa Saad4, Octavio Luiz Franco5,6, Heba N. Deif 2*
... xer virulence gene, the quinolone resistance-determining region (QRDR) genes parC, parE and gyrA and the macrolide and lincomycin resistance genes, rpID and rplV genes were undetected. The role of H2S production in the pathogenesis of M. arginini and M. ovipneumoniae needs further in vivo studies.
Keywords | Antibiotic-resistance, Biofilm, H2S, Mycoplasma, Sheep
...
Hongsen Xu*, Xiaoni Wang, Tie Tian, Changyu Zhao, Denghang Yu and Jun Liu
...ctrum β-lactamases, quinolone resistance determinants and tetracycline-resistance) confirmed antibiotics sensitivity of this bacterium. Artificial infection showed that the strain could cause similar symptoms to those of naturally infected crayfish, and the lethal dose 50% was 1.52 × 106 CFU/g crayfish. Serious histopathological changes, such as cell degeneration and necrosis, hemorrhage and inflammatory cell infiltration, were found in diseased cra...
Azhar Ali1, Faheem Ahmed Khan2, Wu Di3, Huang Chunjie3, Muhammad Rizwan Yousaf1, Bilal Ahmed1, Farwa Shakeel1, Nuruliarizki Shinta Pandupuspitasari1, Windu Negara2, Bambang Waluyo Hadi Eko Prasetiyono1*
... macrolides, bacitracin, quinolones, β-lactams, and aminoglycosides, which correspond to antibiotics often administered to both animals and humans. An important discovery in this study is the recognition of Enterobacteriaceae as the predominant family in the phylum Proteobacteria, together with enterococcus species from the phylum Firmicutes, which possess numerous antibiotic resistance genes associated with health risks. The presence of antibiotic-resist...
Rico Anggriawan1*, Widya Paramita Lokapirnasari2, Sri Hidanah3, Muhammad Anam Al Arif4, Diyah Ayu Candra5
...s a broad-spectrum fluoroquinolone antibiotic. On commercial poultry farms in Indonesia, the combination of enrofloxacin and tylosin Tylosin and enrofloxacin are often used together as they have a synergistic action against gram-positive and gram-negative bacteria. However, overuse of antibiotics can lead to drug residues in the final product, potentially jeopardizing the health of consumers. This research aims to identify the number of cases and residues of e...
Mona F. Shousha1*, Aml M. Ragab2 and Salwa M. Helmy1
...ses and plasmid-mediated quinolone resistance genes in Salmonella isolates. First, 800 internal organs (heart, liver, intestine, and yolk sac) were collected from 200 infected broilers to genetically analyze their recovered Salmonella antimicrobial resistant genes. Ten isolates of Salmonella were recovered: two (20%) for each S. enterica serovar Grampian, S. enterica serovar Kentucky, and S. enterica serovar Blegdam and then one (10%) for each S. enterica sero...
Dalia G. Ali1; Gamal F. M. Gad1; Osman A. O. Ismail2; Hala R. Ahmed1*; Reham A. Ibrahem1
Sarah Sonbol1; Nahla A. Hussein2*
Novel Research in Microbiology Journal (2024), 8(5): 2653-2665
...iotics, aminoglycosides, quinolones, and sulphonamide. The resistance genes showed different distributions among the core, dispensable and/or strain-specific genomes, ranging from an almost equal distribution in E. coli and S. enterica to higher occurrence in the dispensable/ strain specific genome in K. pneumoniae. Depending on the bacterial genus, cell envelope acting antibiotics occupied between 15 % - 30 % of the core genome resistome. In addition, the seq...
