Search for Nephrotoxicity

Comparative Effects of Radon Inhalation According to Mouse Strain and Cisplatin Dose in a Cisplatin-induced Renal Damage Model

Kaori Sasaoka¹, Takahiro Kataoka¹, Norie Kanzaki¹, Yusuke Kobashi¹, Akihiro Sakoda², Yuu Ishimori² and Kiyonori Yamaoka^1,*

...ers; however, it induces nephrotoxicity caused by oxidative stress. Here, we investigated whether radon inhalation has different effects against CDDP-induced renal injury in two mouse strains differing in radiosensitivity, and determined the appropriate dose of CDDP combined with radon inhalation for highly radiosensitive mice. CDDP was administered at 20 mg/kg weight to C57BL/6J and BALB/c mice after radon inhalation at 1000 Bq/m³and 2000 Bq/m

Haematological and Histopathological Analyses of Levofloxacin Induced Toxicity in Mammals

Chaman Ara¹*, Asmatullah¹, Sehrish Kanwa¹, Asma Chaudhary², Ayesha Siddiqua¹

... induced hepatotoxicity, nephrotoxicity and its likely noxious effects on spermatogenesis in mammals. Forty mice, randomly categorized into four groups (N=10) were administered orally with different concentrations of levofloxacin (0.00, 9.37, 18.75 and 37.50µg/g BW of mice) for 30 days consecutively. Mice were sacrificed on 31^st day (24 hours after last dose administered) under deep chloroform anaesthesia. Blood was extracted through cardiac p...

Protective Effect of Tamarind against Renal Injury Induced by Gamma Rays

Sameh S. Tawfik, Ahmed A. Elkady* and Ehab T. Mohamed

...nst γ-rays-induced nephrotoxicity in irradiated rats was investigated. Forty albino-rats were divided into four groups: Control, rats were orally administered the vehicle for 6weeks, TSE-treated (each rat received 230mg TSE; once daily, for 6weeks), irradiated (animals subjected to whole body γ-rays (8Gy), and TSE-treated and irradiated (each rat received 230mg TSE; once daily for 6week, then one-hour later after last-treatment, rats were exposed t...

Insight into the Mechanism of Doxorubicin-induced Nephrotoxicity through Gene Expression Analysis of Oxidative Stress, Kidney Injury and Inflammation Markers

Uzma Jabeen¹, Asmat Salim²*, Irfan Khan², Nadia Naeem³ and Rubina Mushtaq⁴

Biochemical and Histopathological Effects of Repeated Low Oral Doses of Malathion, Metalaxyl and Cymoxanil on Different Tissues of Rats

Ahmed H. Massoud¹, Mohamed S. Ahmed², Moustafa Saad-Allah¹, Aly S. Derbalah¹, Ashraf Albrakati³* and Ehab Kotb Elmahallawy⁴*

...ally, hepatotoxicity and nephrotoxicity were obvious in rats treated with cymoxanil, meanwhile, neuronal and pulmonary changes were nearly the same in all doses of the used pesticides. Taken together, our study recommends examining pesticides for their possible adverse effects on animals and humans in case of repeated use, even in small doses, before their application to agricultural fields.

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Chia Seeds Oil Inhibits Hepatic Resistance to Doxorubicin Via Suppressing Cyp3-A4 and Mrp-1 in Male Albino Rats

Shaimaa A.Tawfik2,3, EL S.T. Awad1*, Hoda O.Abu Bakr1, Amira M.Gamal-Eldeen4, Esmat Ashour2, Ismail M.Ahmed1

...ssion in hepatotoxicity, nephrotoxicity and cardiotoxicity induced by DOX in male albino rats evidenced by a significant enhancement in the activity of ALT, GGT, LDH, AST, also creatinine and uric acid. CSO induced antioxidant activity GSH, CAT and inhibited MDA. Histopathological examination in sections of liver, kidney and heart tissues were confirmed these findings. In liver tissues, DOX resulted in an observable induction in CYP3A4 and MRP-1, while CSO/DOX...

Therapeutic Effects of Rocket Leaves (Eruca sativa) against Hepato-Renal Toxicity Caused by Xylene in Wistar Rats

Rahma Boukarine*, Leila Hamdi and Kamel Khelili

...duced hepatotoxicity and nephrotoxicity in wistar rats, while the combination of this solvent with rocket aqueous extract (Eruca sativa) attenuated this toxicity thanks to its antioxidant property.

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Erlotinib and Garcinia Cambogia Prevent Adenine Induced Nephrotoxicity in Adult Male Albino Rats Through Modulating EKR1/2, STAT3, and p53 Apoptotic Pathways

Dalia M. Amin1*, Noha Mohammed Halloull1, Walaa E. Omar2, Basma A. Ibrahim2, Nahla M. Ibrahim1

Deleterious Effects of Mercuric Chloride Toxicity Initiated Partially from Physiological Disorder of Kidney, Immunocytes and Redox System, can be Reversed by Resveratrol Administration

Rusul Adnan Dawood, Hasan F.K. Alghetaa*

The Protective Effect of Ellagic Acid on Cyclophosphamide Induced Renal Damage in Rats

Muhammad Nasir Bhaya^1,2* and Hikmet Keles²

Histophysiological Effect of Rosuvastatin on the Kidney in Male Albino Rats

Haneen Imad Al-Sultani1*, Ahmed Obaid Hussain1, Hazar Shakir Saleh2

...tin in high doses causes nephrotoxicity.

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Aqueous Myrrh Extract Relieves Oxidative Stress-Dependent Nephrotoxicity Induced by Ethanol in Male Rats

Abeer Alahmari^1,2*

...idative stress-dependent nephrotoxicity caused by ethanol in rats. Male Sprague‒Dawley rats orally received 40% ethanol (3 g kg-1) and were then orally treated with (500 mg kg-1) AME daily for 30 days. Kidney function, oxidant and antioxidant status, and histopathology alterations in renal tissue were measured. Animals that received ethanol displayed nephrotoxicity, as confirmed by markedly increased serum creatinine, ur...

Effects of Bee Venom on Cadmium Toxicity in Albino Rats

Mariam Ismail Ali¹*, Rania Helmi Abdou¹, Mary Ayad Sargious², Omnia Mohamed Khattab², Kawthar Abdelwahed Elhady¹

...chloride hepatotoxicity, nephrotoxicity, and neurotoxicity in rats. The study found that cadmium treatment in rats increased inflammatory markers (TNF-α 264.3% and IL-1β 170.7%), and oxidative markers(MDA 140.5%), Higher liver enzymes, histopathological lesions, and genes expression screened for hepatotoxic effects. Bee venom effectively reduced inflammation (TNF-α 49% and IL-1β 41.4%) and oxidation (MDA 36.8%), reduced liver enzymes, and...

Histological, Immunohistochemical Expression and Biochemical Changes in the Liver and Kidney of Wistar Rat Neonates after Prenatal Exposure to Copper Oxychloride

Sherine Abbas¹, Hadeer M. Shosha², Hala M. Ebaid², Heba Nageh Gad El-Hak², Heba M. A. Abdelrazek³*

Nephroprotective Effect of Alcholic Extraction of Tribulus terrestris Against Lead Acetate Toxicity on Kidney in Male Rats

Mayada Sahib Hassan¹*, Hayder Talib Mahdi¹, Sajaa R. Al-Saedi¹, Ali Farid Shakir¹, Ali J. Al-Nuaimi¹, Marwa Sabah Majed¹, Ridha Adel Fahad¹, Karar Ali Kadhim¹, Mustafa Ali Noor¹, Ameer Hameed Kadhim¹, Hussein Ali Mohammed Hadi¹, Zainab Amori Oribi², Mazin Talib Abbas³, Mahdi S. Hassan⁴

...nst lead acetate-induced nephrotoxicity. In experimental animals, forty adult male albino rats were utilized. Four groups of animals were used in the study. Ten male rats each group are used: Group 1 (control group): For 28 days, the animals were given distilled water orally. Group 2 (lead acetate group): For seven days, animals in this group received intraperitoneal injections of lead acetate at a dose of 30 mg/kg B.W. every day, depended on LD50. Group 3 (Tr...

Effects of Gamma-Irradiated Aqueous Extract of Turmeric on Doxorubicin Induced Cardio-Nephrotoxicity in Male Rats

A.M. Abdul Azeem¹, A.N. El shahat¹, Mohamed H.M. Abd El Megid² and Amal A. Mansour¹*

...n (DOX)‑induced cardio-nephrotoxicity in male rats. The result indicates that the total phenolic content, antioxidant activity and curcumin content of turmeric powder were significantly increased by γ-irradiation. The results of biological study revealed that inoculation of DOX (3 mg/kg b.w./week/6 weeks) to rats induced cardiac and renal dysfunction, inflammation, and oxidative stress with significant reduction of cardiac and renal antioxidant paramet...

Effect of Acacia nilotica Against Nephrotoxicity Induced by Gentamicin in Rat: Role of Antioxidants, Anti-Inflammatory and Antiapoptotic Markers

Saed A. Althobaiti¹, Safa H. Qahl², Layaly Elsigar¹, Lobna M.A. Gurafi¹, Zeinab Kanani¹, Mohamed Mohamed Soliman³* and Omaima Nasir¹

...sponsible for gentamicin nephrotoxicity. Recent research has shown that Acacia nilotica extract (AN) retains antioxidant and anti-inflammatory activity. This study assessed AN’s inhibitory impact on rat nephrotoxicity induced by gentamicin. Twenty-four male Wister rats have sub-divided into 4 groups, the control one received saline; the second group was administered with AN extraction (5%) for fifteen days; group-3 rat...