Jiajia Wan1,2, Chi Zhang3, Xiaodi Li3, Longkang Liu3, Linxiu Peng3,4, Yuejian Liu2, Yang Qiu2, Guokai Wu2, Bo Zhang3*, Yan Wang3* and Tonghui Ma3*
...for the first time, that aquaporin-9 (AQP9) is expressed in AMs and undergoes significant up-regulation following lipopolysaccharides (LPS) administration. AQP9 gene knockout (AQP9 KO) mice exhibited markedly attenuated alveolar hemorrhage and interstitial edema in an LPS-induced ALI model compared with wild-type (WT) littermates. The mitigated lung injury in AQP9 KO mice correlated with significantly alleviated pulmonary inflammation as indicated by significa...
