Alzheimer’s Disease: Pathogenesis, Hypothesis and Management
Alzheimer’s Disease: Pathogenesis, Hypothesis and Management
Rabia Anjum
ABSTRACT
Alzheimer’s disease (AD) is a degenerative disease of neurons in which brain cells started to loss their functions. Its main cause is dementia which results in decreased activity of brain such as thinking and increased dependence on others to fulfill the daily tasks. The pathological identification of AD is beta amyloid accumulation or development of neurofibrillary tangles of tau proteins. Currently different hypothesis was proposed in the progression of disease which are amyloid cascade, tau and cholinergic hypothesis. Other than that age, family history, injury, high blood pressure and genetic may play an important role in the disease development. Current AD treatment are acetylcholinesterase inhibitors are easily accessible in the market to relief the AD primary symptoms but did not cure it. AD treatment needs a therapeutic approach to minimize its progression. This review focuses on the understanding of disease, hypothesis and treatment of disease to slow its progression.
Novelty Statement | Amidst the challenges posed by the current medications, the narrative extends into the realm of experimental drug therapy, shedding light on the potential breakthroughs, such as aducanumab, while acknowledging the ongoing quest for more targeted treatments that address the fundamental causes of this multifactorial neurodegenerative disease.
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December 2023
Vol.38, Iss. 2, Pages 137-236
