Attenuated Rift Valley Fever Virus (NMP18) Chemically for Vaccine Development
Attenuated Rift Valley Fever Virus (NMP18) Chemically for Vaccine Development
M.S. Wassel1; Elham A. El-Ebiary1; Soliman, Y.A.l and El-Sayed, M.M.2
ABSTRACT
Serial treatment of RVF virus ZH501 with nitrous acid and 5-flourouracil has been employed to derive an attenuated strain of Rift valley Fever virus (NMP18) for use as alive virus vaccine besides studying its safety, potency, and the duration of immunity in pregnant and non-pregnant sheep and cattle as well as remaining its antigenic and immunogenic power in animals using its protein analysis and Western blotting.
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December 2004
2004
