Bacteriophage endolysins and their role in eradication of bacterial biofilms
Bacteriophage endolysins and their role in eradication of bacterial biofilms
Anugrah Masih; Aditi Singh*
ABSTRACT
Biofilm is the protective coating that the bacteria use to thrive in their environment
without being damaged by radiation or the effects of antibiotics. Nosocomial infections that
are often caused by biofilms have been demonstrated to be very challenging to cure because of
their complicated molecular structure and resistance to antibiotics. Biofilms of bacteria that
form on the medical equipment pose a risk to patients and facilitate the transmission of
infection. Progress has been made in eliminating bacterial biofilms by combining
bacteriophage with antibiotics for a synergistic impact and employing the phage-lysin
efficiently. The aim of this study was to explore the potential efficacy of phages and lysins
alone and/ or in conjunction with antibiotics to combating biofilm conformation and
eradication. This review article is broadly divided into two parts; the first section focused on
molecular mechanism of biofilm formation and risk of bacterial biofilms in the hospital
settings. The second part of the review is giving an insight on bacteriophage derived lytic
protein-endolysin, which has emerged as a potential alternative to eliminate bacterial biofilms,
and should be explored to combat infections caused by them.
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June 2023
Vol. 7, Iss. 3,
