Discovering the Potential of Teak, Turmeric, and Ginger in Broiler Chicken Gut Health: A Network Biology Perspective on IL-6 Inhibition
Feri Eko Hermanto1, Yuli Frita Nuningtyas1, Filoza Marwi1, Fajar Shodiq Permata2, Agus Susilo1, Muhammad Halim Natsir1*
1Faculty of Animal Sciences, Brawijaya University, Malang, East Java 65145, Indonesia; 2Faculty of Veterinary Sciences, Brawijaya University, Malang, East Java 65145, Indonesia.
*Correspondence | Muhammad Halim Natsir, Faculty of Animal Sciences, Brawijaya University, Malang, East Java 65145, Indonesia;; Email: emhanatsir@ub.ac.id
Figure 1:
Biological network topology contains proteins involved in mucosal immunity, digestive health, and proteins involved in mucosal immunity and digestive health.
Figure 2:
Identification of the level of importance of a protein in a biological network using 11 Cytohubba algorithms (A) and a summary of the proteins that consistently have the highest scores (B).
Figure 3:
Interaction chemistry among selected compounds according to the molecular docking analysis.
Figure 4:
Structural stability of selected complexes according to the value of RMSD backbone atom (A), RMSF of per-residue (B), binding free-energy estimations (C), RMSD of ligand conformation (D), and the number of hydrogen bonds (E).