Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens
Novel Research in Microbiology Journal (2024), 8(5): 2604-2631
Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens
Subhasmita Mallik1; Samikshya Nayak1; Arpita Panda2; Smrutirekha Behera1; Kamalakanta Swain2; Archita Patra1; Rukmini Mishra1; Jatindra Nath Mohanty1*
ABSTRACT
In recent decades, microbial resistance to antimicrobial drugs has emerged as a global health crisis. Therefore, it is crucial to develop alternative therapeutic strategies to address the growing threat of multi-drug resistant (MDR) pathogens. Researchers and clinicians are increasingly focusing on plant-based products due to their antibiotic properties and lack of associated antibiotic resistance. Plant-based nanoparticles present several benefits, including their natural origin, biocompatibility, and potential for targeted delivery. Our aims in this review were exploration of the complexities and limitations of plant-based phytochemical extraction processes and addressing the challenges of synthesizing nanoparticles for combating multidrug-resistant (MDR) pathogens. It also examined the effectiveness of phyto- based nanoparticles in drug delivery systems to treat MDR infections; both alone and in combination with antibiotics, and provided a critical assessment of their potentials as a research avenue. For this, we have taken the diverse methodologies that were previously used to select the best possible process to tackle MDR pathogens using plant extracts. Although using plant-derived products and nanoparticles is a novel approach to address the antimicrobial drug resistance; however, detailed researches are necessary to explore their antibacterial attributes. Specifically, transcriptome profiling should be employed to identify therapeutic molecules from plant-based products that can effectively combat MDR bacteria before synthesis of nano-drugs. The outcomes of this study will enable the researchers to obtain the best approaches to tackle MDR pathogens through using the nano-based phytochemicals.
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