Dose Dependent Effects of Lemon Peel Oil on Oxidative Stress and Psychological Behaviors in Rats
Sarwat Yousuf1, Shaista Emad2 , Mohammad Misbah ur Rehman3, Zehra Batool4, Sara Qadeer5, Yousra Sarfaraz1, Sheeza Sheikh1, Sana Sadaf6 and Tahira Perveen1,*
1Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi-75270, Pakistan
2Department of Biochemistry, Jinnah Medical and Dental College/Sohail University, Karachi-74800 Pakistan.
3Hussain Lakhani Hospital, Iqra University, Karachi, 74600, Pakistan
4Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
5Department of Biochemistry, Sir Syed College of Medical Sciences, Karachi, Pakistan.
6Department of Biochemistry, Faculty of Health and Medical Sciences, Hamdard University, Karachi, Pakistan.
* Corresponding author: tahiraatiq@hotmail.com
Fig. 1.
Dose dependent effects of lemon peel oil on open field. (a) Number of square crossed and (b) Time spent in central area. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, **p<0.01 as compared to control animals.
Fig. 2.
Dose dependent effects of lemon peel oil on (a) light/dark transition box and (b) forced swim test. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, *p<0.05, **p<0.01 as compared to control animals.
Fig. 3.
Dose dependent effects of lemon peel oil on combine forepaw and hindpaw strength by Kondziela’s inverted screen test. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, **p<0.01 as compared to control animals.
Fig. 4.
Dose dependent effects of lemon peel oil on lipid peroxidation. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, *p<0.05, **p<0.01 as compared to control animals.
Fig. 5.
Dose dependent effects of lemon peel oil on antioxidant enzymes (a) superoxide dismutase and (b) catalase activity. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, *p<0.05, **p<0.01 as compared to control animals.
Fig. 6.
Dose dependent effects of lemon peel oil on plasma corticosterone level. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, *p<0.05, **p<0.01 as compared to control animals.