Dose Dependent Effects of Lemon Peel Oil on Oxidative Stress and Psychological Behaviors in Rats
Sarwat Yousuf1, Shaista Emad2 , Mohammad Misbah ur Rehman3, Zehra Batool4, Sara Qadeer5, Yousra Sarfaraz1, Sheeza Sheikh1, Sana Sadaf6 and Tahira Perveen1,*
1Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi-75270, Pakistan
2Department of Biochemistry, Jinnah Medical and Dental College/Sohail University, Karachi-74800 Pakistan.
3Hussain Lakhani Hospital, Iqra University, Karachi, 74600, Pakistan
4Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
5Department of Biochemistry, Sir Syed College of Medical Sciences, Karachi, Pakistan.
6Department of Biochemistry, Faculty of Health and Medical Sciences, Hamdard University, Karachi, Pakistan.
Fig. 1.
Dose dependent effects of lemon peel oil on open field. (a) Number of square crossed and (b) Time spent in central area. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, **p<0.01 as compared to control animals.
Fig. 2.
Dose dependent effects of lemon peel oil on (a) light/dark transition box and (b) forced swim test. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, *p<0.05, **p<0.01 as compared to control animals.
Fig. 3.
Dose dependent effects of lemon peel oil on combine forepaw and hindpaw strength by Kondziela’s inverted screen test. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, **p<0.01 as compared to control animals.
Fig. 4.
Dose dependent effects of lemon peel oil on lipid peroxidation. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, *p<0.05, **p<0.01 as compared to control animals.
Fig. 5.
Dose dependent effects of lemon peel oil on antioxidant enzymes (a) superoxide dismutase and (b) catalase activity. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, *p<0.05, **p<0.01 as compared to control animals.
Fig. 6.
Dose dependent effects of lemon peel oil on plasma corticosterone level. Values are mean±SD (n=6). Significant difference was obtained by Tukey’s post hoc test, *p<0.05, **p<0.01 as compared to control animals.