Effect of fish oil on growth performance and immune response in experimentally infected broiler chicken with avian influenza virus H9N2
Effect of fish oil on growth performance and immune response in experimentally infected broiler chicken with avian influenza virus H9N2
Effect of fish oil on growth performance and immune response in experimentally infected broiler chicken with avian influenza virus H9N2
Ihsan Ali1#, Asim Aslam1*, Habib-ur-Rehman2, Beenish Zahid3, Ishtiaq Ahmed1
ABSTRACT
Avian influenza (AI) is an important infectious disease of poultry which cause
immune suppression and immune organs damage in broilers. Supplementations of
fish oil (FO) enhance the immune status and subside inflammation. This study was
design to observe the effects of Fish oil on lymphoid organs through
histopathology, growth performance and antibody response in H9N2 challenged
broilers. A total of 80 chicks were divided in to 4 groups A, B, C & D. Group A and
B were challenged with AI virus (H9N2) on 21 day of age, group B and C were
treated with 3% FO while group A and D were treated with cooking oil. For isolation
of virus, 21 samples were collected, out of which 8 (40%) were positive for H9. The
virus titer was ranged from 1:64 to 1:512. The body weight gain of FO
supplemented broilers was higher than broilers receiving cooking oil (CO) while the
FCR of FO treated broilers was significantly lower than broilers receiving diet with
CO before virus inoculation, furthermore a significant difference was observed in
FCR after challenged, with highest value of group A, followed by group D, B and C.
The Geometric mean titer (GMT) for H9N2 and Newcastle Disease Virus (NDV)
were recorded weekly up to 42 day of age by haemagglutination inhibition test. The
mean GMT for H9N2 of group A, B, C, and D after challenge were 76.0, 273.7, 0.5
and 0.35, respectively. However, after challenged the highest GMT for NDV was
observed in group C with 158.8, followed by group B, D and A with GMT of 72.6,
49.3, and 11.32, respectively. Congestion, depletion of lymphocytes, dysplasia of
thymic lobules, necrosis, disappearance of lymph follicles and interfollicular edema
were the prominent histopathological changes observed in challenged group. It is
concluded that fish oil improve the growth performance and immune response in
broilers chicken against avian influenza virus infection.
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