Effects of Nano-Cerium Oxide and Alpha Lipoic Acid on Sciatic Nerve Regeneration in Rats
Effects of Nano-Cerium Oxide and Alpha Lipoic Acid on Sciatic Nerve Regeneration in Rats
Dhuha Adel Yasser*, Ammar M. Hashim, Rafid Majeed Naeem
ABSTRACT
Peripheral nerve injuries are diverse and are primarily the result of trauma. Blunt trauma comprises contusion, laceration, stretching, traction, penetrating, and perforating injuries Cerium oxide nanoparticles possess antioxidant qualities, and utilizing this nanoparticle can safeguard neuronal cells from cell death caused by Alzheimer’s disease. Objective, the objective of this research was to assess how Alpha lipoic acid and Nano cerium Oxide impact the regrowth of sciatic nerve rats. Methodology, thirty-six adult animals using, the animals were separated into three groups (n=12 of each one). The first group (Control)(CG) was left without treated. The second group was treated orally with alpha lipoic acid. a third or (mix group) treated with alpha lipoic acid and nano-cerium oxide orally. Samples from the nerve were collected at 4th, 8th, and 12th weeks after the surgery. Results, the histopathological findings showed that the (Mix group) had the best response compared to the control group and (alpha group) and showed notable nerve damage and some signs of regeneration as time passed. Although there are signs of significant high regeneration specifically at 12 weeks of Mix group showed only 9(25%) of still nerve damage, while the ALA group showed 15(41.6%) at 12 weeks, in addition, the control group showed 24(66%) of still nerve damage which appeared as delayed nerve regeneration at the end of the experiment. This variability indicates that the control and alpha lipoic acid group may have some advantages, but it is not as reliable and successful as the (mix group), which demonstrates more consistent and strong indications of nerve regeneration. Conclusion, the use of nano-cerium oxide and alpha lipoic acid enhanced the nerve regeneration due to Therapeutic potential of nano-cerium oxide and alpha lipoic acid making them a possible new treatment for nervous system regeneration.
Keywords | Sciatic nerve injury, Nano cerium oxide, Alpha lipoic acid, Neurotmesis, Rats
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