Effects of Recombinant Porcine Epidermal Growth Factor on Diarrhea, Growth Performance and Intestinal Development in Healthy and Piglets with Enteritis
Effects of Recombinant Porcine Epidermal Growth Factor on Diarrhea, Growth Performance and Intestinal Development in Healthy and Piglets with Enteritis
Wenjun XU1, Fenghua Li2, Yanan Wang3, Wei Zhou1, Bingbing Xia1 and Jun Zhao1,4*
ABSTRACT
Studies had shown that epidermal growth factor could promote intestinal development and improve growth performance of early weaned piglets. There was still insufficient data on that EGF could alleviate intestinal damage caused and reduce the degree of diarrhea by viral infection. In this study, twenty-four 10-day-old piglets divided into four groups. Group 1and Group 2 were oral administration of 2×105.5TCID50 for TGEV challenge on day 4. rEGF solution (400μg/day/pig) was orally administered for 14 days from day 4 of the trial in Group 3 and Group 4. The pigs were euthanized by electric shock on day 17. The experiment results show that compared to group 1, average time of relieving diarrhea had a tendency to improve by rEGF treatment in group 2 (P=0.08). The symptoms of enteritis were significantly improved. ADG of second week in group 2 had tendency to increase(P=0.07) compare with group 1 and group 2 had higher final BW. ADG of the first week and second week, ADG of the first week and ADG of second week in group 4 were greater than in group 3(P < 0.05). The length of villi in the jejunum and ileum (P < 0.05) was longer in the rEGF treatment group 4 than in control groups 3.The VH/CD of the jejunum of group 4 treated with rEGF significantly improved also (P < 0.05). In summary, the results indicated that oral administration of recombinant rEGF alleviate intestinal damage caused by TGEV challenge, promotes the health of the intestine and growth rate in piglets.
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