Efficacy of Mimosa Pudica Ethanol Extract Cream in Monobenzone-Induced Vitiligo in Rats
Efficacy of Mimosa Pudica Ethanol Extract Cream in Monobenzone-Induced Vitiligo in Rats
Defi1, Endy Juli Anto2, Jekson M. Siahaan3, Hadyanto Lim4, Fotarisman Zaluchu5*
ABSTRACT
Background: Vitiligo is a skin disorder characterized by well-defined depigmented macules caused by the progressive loss of melanocytes. Mimosa pudica L. (sensitive plant) leaves are rich in flavonoids and phenolic compounds, both known for their high antioxidant activity. This is the first study to investigate Mimosa pudica ethanol extract cream for vitiligo treatment on reducing vitiligo lesion size and promoting skin repigmentation in a black rat model. Methods: A total of 24 black rats were induced with vitiligo using 40% monobenzone for 50 days. The rats were then divided into four equal groups, consist of six rats per group. One group served as the positive control and received no treatment, while the other three groups were treated with Mimosa pudica L. ethanol extract cream at concentrations of 50%, 75% and 90%. The extract cream was applied three times per week for 30 days. Depigmentation and repigmentation areas were measured in all groups on Day 0, 14 and 30. Results: All consentration of Mimosa pudica L. ethanol extract cream had a positive impact on the black rat model of vitiligo (p<0.001). Yet, the group treated with 50% Mimosa pudica L. ethanol extract cream showed the greatest repigmentation and the smallest vitiligo area compared to all other groups (p<0.05). Conclusion: The 50% ethanol extract cream from Mimosa pudica L. leaves is an effective alternative treatment for vitiligo.
Keywords | Mimosa pudica L., Vitiligo, Antioxidants, Repigmentation, Rats
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