Evaluating the Efficiency of gamma Irradiated Frankincense against Isoprenaline Induced Myocardial Infarction in Rats
Evaluating the Efficiency of gamma Irradiated Frankincense against Isoprenaline Induced Myocardial Infarction in Rats
Ashraf M. Mounir, A.N. El shahat* and A.M. Abdul Azeem
ABSTRACT
Isoprenaline (ISO) is one of synthetic catecholamine that can be used as a model to produce myocardial infarction (MI). Frankincense is a gum resin that possesses anti-inflammatory and antioxidant activity. Gamma-irradiation is used for decontamination of Boswellia tears to achieve satisfactory microbiological quality and public health safety. Hence, examining the effect of gamma-irradiation on the contents of Boswellia oleo-gum resin and also investigating the role of gamma-irradiate frankincense aqueous extract (GFAE) against ISO-induced MI in rats were the two aims of this study. The total phenolic content and total flavonoids of frankincense has been significantly increased under the effect of gamma-rays in this work. Injection of isoprenaline hydrochloride (100 mg/ kg B.Wt./day) to rats resulted in cardiac oxidative stress, inflammation, hyper-lipidemia and increase cardiac marker enzymes. Treatment of rats with GFAE (45 mg/kg/day) prior to injection of ISO provide significant cardio-protective effects evidenced by an obvious reduction in the level of cardiac marker enzymes, inflammatory factors and lipid contents with marked improvement in the cardiac antioxidant status and reduction of lipid peroxidation relative to untreated infarcted group. The study concluded gamma irradiation could be used as an efficient method for sterilization and increasing the active contents of frankincense. Also, gamma-irradiated frankincense can be used as an effective cardio protective natural agent in MI.
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February 2019
Vol. 51, Iss. 1, Pages 1-398
