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In Silico Analysis of Genome Wide Non-Synonymous Single Nucleotide Polymorphisms in Indigenous Cattle Breeds of Pakistan

In Silico Analysis of Genome Wide Non-Synonymous Single Nucleotide Polymorphisms in Indigenous Cattle Breeds of Pakistan

Umer Farooq1,2, Nimra Murtaza2, Abubakar Siddique1, Bilal Saleem1, Obaid Ur Rehman1, Nageen Zahra1, Muhammad Uzair1, Muhammad Naeem Riaz1,3* and Muhammad Ramzan Khan1*

1National Institute for Genomics and Advanced Biotechnology (NIGAB), National Agricultural Research Centre, Park Road, Islamabad, Pakistan
2Department of Biosciences, COMSATS University Islamabad, Park Road, Islamabad, Pakistan
3Animal Biotechnology Program, Animal Sciences Institute, National Agricultural Research Centre, Park Road, Islamabad, Pakistan
 
* Corresponding author: mrkhan@PARC.gov.pk; naeemriaz@parc.gov.pk

Fig. 1.

Bioinformatics workflow for analyzing whole genome sequencing data.

Fig. 2.

Number of single nucleotide polymorphism (SNP) distribution by chromosome (A) and number of insertion/deletions (InDels) distribution by chromosome (B).

Fig. 3.

ClueGO gene ontology analysis of 134 genes with deleterious nsSNP identified in all samples. ClueGO identifies the enriched go terms and visualizes them in grouped annotation network. This network shows the relationship between the terms based on the similarity of their associated genes. Each node represents a gene ontology term and the associated genes.

Pakistan Journal of Zoology

October

Pakistan J. Zool., Vol. 56, Iss. 5, pp. 2001-2500

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