Molecular Mechanism of Sappan Wood Extract in Rat Liver and Kidney Models with Iron Overload
Molecular Mechanism of Sappan Wood Extract in Rat Liver and Kidney Models with Iron Overload
Tanendri Arrizqiyani1,2, Mas Rizky A. A. Syamsunarno3, Ratu Safitri4*
Gene relative expression of TfR2, Flt and Hamp in liver and kidney of rats organ in various treatment; Gene relative expression of Flt in liver (a); Gene relative expression of TfR2 in liver (b); Gene relative expression of TfR2 in kidney (c); Gene relative expression of Flt in kidney (d); Gene relative expression of Hamp in kidney (e); Gene relative expression of Hamp in liver (f); P<0,05 vs iron dextran.
Schematic illustration of the routes by which hepatocytes absorb transferrin bound iron and non-transferrin bound iron (see to the text for further details). Transferrin receptor 1 (TfR1), transferrin receptor 2 (TfR2), divalent metal transporter 1 (DMT1) and iron transport stimulator (SFT). (Trinder et al., 2002).
The protein-protein interaction (PPI) network related TfR2, Ftl and Hamp iron overload constructed with GeneMANIA.
