Molecular Metabolism in Treatment of High Altitude Polycythemia with Duoxuekang Capsule
Molecular Metabolism in Treatment of High Altitude Polycythemia with Duoxuekang Capsule
Jia Nie1*, Ze Weng Yong Zhong1, Di Wang2 and Ming Jian Li3
ABSTRACT
The objective of this study was to explore the molecular metabolic mechanism of Duoxuekang capsule curing high altitude polycythemia (HAPC) from two aspects of efficacy and mechanism. Sixty SPF grade male SD rats aged 1 month were purchased from the experimental animal institution of Sichuan Provincial People’s Hospital and tested. According to the weight of rats, they were randomly divided into 6 groups, each containing 10 rats. Partial living environment of rats was simulated by high altitude hypobaric chamber, and group N and group M were established. Three groups of rats were given different doses of Duoxuekang capsules by gavage, and DXKH group, DXKM group and DXKL group were established. One group of rats were given Nordicam and group C was established. The activities of LDH and EPO in kidney tissue and SDH in the brain tissue of the rats in the group using Duoxuekang capsule were significantly higher than those in the group M (P<0.05). Their RBC, HGB, HCT and whole blood viscosity were under M’s performance, and the effects of DXKH and DXKL groups were more significant. There were sixteen differential metabolites in the treatment of HAPC with Duoxuekang capsule, involving nine metabolic pathways. Four of them were related to the pathogenesis of HAPC, including glycerol, pyrimidine, arginine, proline and glutathione metabolism (P<0.05). Duoxuekang capsule has obvious anti-hypoxia effect and can improve the pathological changes of viscera in model rats. The pathogenesis of HAPC is complex, and Duoxuekang capsule can act on multiple targets of the body, such as oxidative stress, inflammatory reaction, etc., so as to improve the body’s metabolites and treat HAPC.
To share on other social networks, click on any share button. What are these?
