Protective Effects of Oviductus Ranae Mediated HPA Axis Regulation on Depressive Model of Mice
Xiaowei Huang1, Chao Ma1, He Lin1, Yuchen Wang1, Yan Xu1, Guangfu Lv2* and Zhe Lin1*
1School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, 130117, China
2Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, 130117, China
* Corresponding author: linzhe1228@163.com, lvgf@ccucm.edu.cn
Fig. 1.
Effect of OR on the contents of CRH, ACTH and CORT (A), the pathological changes in hippocampal tissues (magnification: 200×) (B), and the expression levels of proteins (C).
CRH, corticotropin-releasing hormone; ACTH, adrenocorticotrophic hormone; CORT, Corticosterone; BDNF, Brain-derived Neurotrophic Factor; TrkB, Trosine kinase B; CREB, Cyclic adenosine monophosphatec response element binding protein; GR, Glucocorticoid Receptor; MR, Mineralocorticoid Receptor. ##p<0.01, compared with control group; **p<0.01, compared with CUMS group.