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Studies on Mechanism of Preventive Effect of Fermentation Product of Calvatia lilacina on Water-Immersion Stress Induced Gastric Ulcers in Mice

Studies on Mechanism of Preventive Effect of Fermentation Product of Calvatia lilacina on Water-Immersion Stress Induced Gastric Ulcers in Mice

De Hu, Jia Wang, Huan Wang, Xiang-Yang Leng, Tian-Yi Zhao* and Shu-Min Wang*

College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, PR China.

 
* Corresponding author: zhaoty@ccucm.edu.cn; wangsm@ccucm.edu.cn

Fig. 1.

Effect of FP of C. lilacina pretreatment on histological sections in the mice stomach. Gastric mucosa histopathological changes are shown following H and E staining (magnification, 200×).

Fig. 2.

Effect of FP of C. lilacina on the activity of pepsin in gastric tissue. Data are expressed means± SD (n= 6). #P <0.05 versus the injury group. **P <0.01, *P <0.05 versus the previous group.

Fig. 3.

Effect of FP of C. lilacina on the related indices of oxidative stress in gastric tissue. Data were expressed means± SD (n= 6). ##P <0.01, #P <0.05 versus the injury group; **P <0.01, *P <0.05 versus the previous group.

Fig. 4.

Effect of FP of C. lilacina on the anti-inflammatory indices in the serum. Data are expressed means± SD (n=6). ##P <0.01 versus the injury group; **P <0.01, *P <0.05 versus the previous group.

Fig. 5.

Effect of FP of C. lilacina on the activation of NLRP3 / ASC / caspase-1 pathway in gastric tissue. Data were expressed means ± SD (n=3). ##P <0.01 versus the injury group; **P <0.01, *P <0.05 versus the previous group.

Pakistan Journal of Zoology

October

Pakistan J. Zool., Vol. 56, Iss. 5, pp. 2001-2500

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