The inhibitory effect of Punica granatum on Escherichia coli and Klebsiella pneumonia Extended spectrum β-lactamase strains
The inhibitory effect of Punica granatum on Escherichia coli and Klebsiella pneumonia Extended spectrum β-lactamase strains
Wafa H. Alamshani*; Faisal Al-Sarraj; Mashail A. Algamdi
ABSTRACT
Each year, millions of people worldwide suffer from urinary tract infections (UTIs),
which are the second most common type of infection in the human body. An infection of the
urinary tract (UTI) affects the urinary bladder, kidneys, and or urethra. In order to eliminate
the urine from the body, it passes through these organs. However, most UTIs are caused by the
uropathogenic Escherichia coli and Klebsiella pneumonia, making treatment more difficult.
Recurrent UTIs can be effectively treated with long-term antibiotics; however, they can have
several adverse side effects, and sometimes they may generate antibiotic-resistant strains. Due
to these downsides, alternative remedies based on plant extracts are increasingly being
considered for the prevention and treatment of urinary tract infections, particularly in the
context of a synergistic antibiotic strategy. There are many medicinal benefits of the
pomegranate (Punica granatum) plant that makes it to be known as a wonder fruit.
Pomegranates are the predominant species that belong to the family Lythraceae. Due to its
extensive range of bioactive compounds, the diverse parts of this P. granatum plant exhibit
significant pharmacological activities. The bioactive compounds of this plant have been shown
to possess several antioxidants; anti-inflammatory, antimicrobial, anti-diabetic, antiatherosclerotic,
and many other biological effects. Consequently, the purpose of this review
was to highlight the inhibitory potential of P. granatum extracts on E. coli and K. pneumonia
pathogens, to be used in the effective management of UTIs.
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February 2023
Vol. 7, Iss. 1,
