Variations in proteins and transaminases following experimental induction of Bisphenol A in mice
Variations in proteins and transaminases following experimental induction of Bisphenol A in mice
Variations in proteins and transaminases following experimental induction of Bisphenol A in mice
Muddasir Hassan Abbasi1, 2, Noor Fatima1, Syed Shahid Imran Bukhari1, Asma Rashid khan3, Nadeem Sheikh2*
ABSTRACT
The current work was aimed to find the effect of Bisphenol A (BPA) which is widely used in the manufacturing of
epoxy resins and variety of plastics to which humans are exposed routinely. BPA (12.5%) was injected in mice for
consecutive 15 days while control animals were not exposed to any treatment (n=3). Serum samples were processed
for the estimation of total protein and albumin and aminotransaminases activity. The sodium dodecyl sulphate
polyacrylamide gel electrophoresis (SDS-PAGE) was also run to analyze protein bands. Statistically significant
increase in total protein contents, albumin and aminotransaminases were noted in sample in comparison with control.
Comparative analysis between experimental and control samples revealed protein fractions (KDa) of 149, 132, 101,
72, 75 and (163, 114, 91, 75, 72, respectively. Conclusively, it can be stated that extensive use of BPA in various
application cause serious health hazards, as noted by changes in serum proteins and transaminases. Therefore,
further investigation of its toxicity is necessary in order to consider it safe.
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