Ali Mohammadi, Mohammad Hossein Ebrahimi
...suffering from knee osteoarthritis (OA). Among them total knee artroplasty is being practised frequently. This method is suitable especially for elderly subjects with limited degree of physical activity. However, most of young subjects are not recommended to be treated with this method owing to high level of physical activities. KineSpring knee implant system was designed for young subjects with knee OA to reduce knee pain, improve sta...
Seyed Mohsen Mirbod
...ustify;">Knee joint osteoarthritis (OA) is a disease which influences the performance of the joint during walking. Various types of knee orthosis have been designed to improve the performance of the subjects, however, such cases are often associate with post-operational complications. The aim of this study is to design an orthosis which is easy to use, economical and effective. A new knee orthosis was designed to improve the performance of OA patients during s...
Shazia Irfan1*, Asima Rani1, Muhammad Arshad2 and Razia Bashir1
...ne of them is Rheumatoid arthritis (RA). The exact cause of RA is still unknown. Reduced activity of antioxidants enzymes because of polymorphisms in antioxidant genes and variations in levels of metals and minerals creates oxidative stress may play some role in progression and pathogenesis of RA. The objective of this study was to investigate the role of Superoxide dismutase 1 (SOD1) gene polymorphism [rs2070424 (–251A/G)] in RA and to compare the level...
Muhammad Mansoor, Zaigham Abbas and Nageen Husssain*
...ed increased symptoms of arthritis and gastrointestinal tract involvement in gluten containing diet group compared with standard diet disease control group. ANA autoantibodies, C3c and renal damage between gluten and standard diet group was non-significant. The remission of SLE manifestations was observed in prednisone treated group except renal damage. From the study it was concluded that gluten intake could worsen the clinical manifestations in SLE patients,...
A. N. Naqvi and K. Fatima*
INCIDENCE OF LIVESTOCK DISEASES IN NOMAL AND NALTAR VALLEYS GILGIT, PAKISTAN
..., tetanus, paralysis and arthritis. In precise, endoparasites were found in 25.3% animals followed by respiratory diseases (24.74%). Most of the cattle (2053) and sheep (926) were found affected with endoparasites, whereas most of the goats (3960) were suffering from respiratory disorders. The seasonal data indicated that the incidence of diseases prevailed was high (33.94%) in winter while it was as low as 14.18% in summer. ...
Jie Yang
...erosclerosis, rheumatoid arthritis, skin melanoma and renal carcinoma) have been reviewed. Taken together, these results indicate that human PGLYRP1 encodes an innate immunity protein that breaks down the structure of microbial cell wall, plays a role both in antibacterial defenses and several inflammatory diseases.
... 
Hafiz Muhammad Arsalan1, Maria Altaf1, Zeemal Seemab Amin1, Muhammad Khalil Ahmad Khan2, Anum Shahzadi1, Hina Mudasser1, Iqra Maqsood1, Nazia Gulshan1, Saira Naseem3
... osteoclasts. Rheumatoid arthritis allied with considerable levels pain, tiredness, disability, reduced distinction life. Precise pathogenesis job rheumatoid factor not known, through formation immune complexes engross establishment harmonize. To determine the correlation between Anti-Oxidants and Biochemical status in Rheumatoid Arthritis patients. 60 clinically diagnosed Rheumatoid Arthritis...
Asmaa A. Darwish
...ated to sheep pneumonia, arthritis and enteritis and spot the light on MMP-2 and MMP-9 diagnostic and prognostic accuracy in these conditions. 80 barki lambs were divided into four groups control group (CG), pneumonic group (PG), arthritic group (AG) and enteric group (EG). Blood samples were collected from the four groups then haematologically, biochemically and statistically analyzed. A significant (P< 0.05) microcytic hypochromic anemia was observed in t...
Neelam Pery*, Nayab Batool Rizvi, Muhammad Imtiaz Shafiq
...c options for rheumatoid arthritis have increased tremendously over the last two decades. The persistent monopoly of the conventional disease-modifying anti-rheumatic drugs over the drug platform has been taken over by a number of biologics including TNFα inhibitors, IL-1 inhibitors, IL-6 inhibitors, and co-stimulatory signal inh...
Syeda Farzana Bibi* and Siraj-ud-Din
Fluorescence Analysis, Extractive Values and Cytotoxic Screening of Crataeva adansonii DC Leaf and Bark through Brine Shrimp Larvae Assay
...sclerosis and rheumatoid arthritis. During the present study ethanolic extracts of leaf and bark parts of C. adansonii were evaluated through cytotoxic activity. Brine shrimp larvae assay was conducted for this purpose. Extractive values of leaf and bark parts were estimated using n-hexane, chloroform, ethanol, methanol, water, and ether as a solvent. 10g of plant powder was dissolved in 200 ml solvent during various extract preparations Fluores...
Neelam Pery1*, Fatima Ijaz1, Nayab Batool Rizvi1, Munawar Ali Munawar1 and Muhammad Imtiaz Shafiq2*
...size: small;">Rheumatoid arthritis is an autoimmune disease with prevalence all over the world. Several therapeutics with different modes of action are available to deal with the disease but have failed to produce universal response leaving a large proportion of patients untreated. This is due to complex pathogenesis comprising a network of signaling pathways. By controlling one pathway, the pathogenesis continues through complementary pathways. Janus kinase a...
Xuya Zhou1, Ying Liu1, Deqin Xu1, Jie Bao1, Yaru Cao2 and Yong Jin3*
...in. The adjuvant-induced arthritis model was established by Paraffin/BCG. We used western blot to explore the protein expression levels of COX-2 and cytochrome P450 (CYP) 4A1. The expression of CYP4A1 was detected by immunohistochemistry. Enzyme-linked immunosorbent assay (Elisa) was used to detect the prostaglandin E2 (PGE-2), 20-Hydroxyeicosatetraenoic acid (20-HETE), endothelin 1 (ET-1) and B-type natriuretic peptide (BNP) in blood serum of diabetes complic...
Haseeb Nisar1, Usman Pasha1, Kiran Hanif1, Rizwan Abid1, Rehan Ahmad Khan Sherwani2, Haja N. Kadarmideen3 and Saima Sadaf1*
...thogenesis of rheumatoid arthritis (RA). Due to the confounding results, reported in several studies, we performed the systematic literature search on IL-6 -572 G/C polymorphism (rs1800796 SNP) and assessed its association with RA in the overall world population, and in the subgroup analysis of Asian and Caucasian populations. The results showed that in overall population, IL-6 -572 G/C shows a significant association towards increased risk of RA in allelic (O...
Guangyu Wang, Xu Tian, Lintao Liu, Junyang Liu, Bo Zhang and Jingming Dong*
... patients with knee osteoarthritis (KOA) and in traditional Chinese medicine, Shujin Huoxue Tablets (SJHXT) is known to be a useful medicine for KOA. The aim of this study was to investigate the effects of SJHXT combined with sodium hyaluronate on synovial inflammation in a patients with KOA. A total of 180 patients with knee osteoarthritis who were treated in our hospital were enrolled as the study subjects who were divided...
Shimaa M. Mansour, Reham M. ElBakrey, Ahmed Orabi, Haytham Ali, Amal A. Eid
...hickens showed bilateral arthritis with
tendons included microscopic changes consistent with the typical ARV infection. Additionally, eight
chickens (8/18) showed stunting and another one chicken (1/18) showed poor feathering while the last
three chickens (3/18) appeared diarrheic. All clinically affected chickens showed varied postmortem
lesions that almost associated with ARV infections. Further molecular detec...
Roheela Yasmeen1*, Laiba Asif1 and Samia Djeffal2
...inflammation, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and actinic keratosis etc. Although, it is good for livestock, its impact on the vulture population has been very deleterious. The present review discusses the chemical structure, uses, and the mechanism of the action of diclofenac and its negative impacts on vulture populations along with less harmful alternatives such as meloxicam, and controlling ...
Ida Bagus Oka Winaya1*, Anak Agung Ayu Mirah Adi1, Putu Henrywaesa Sudipa2, I Gusti Ketut Suarjana2
... meningoencephalitis and arthritis in post-weaning piglets suspected of streptococcosis. The samples were 35 cadaver of post weaning piglets that showed muscle spasm and swollen joint at several villages in Badung Regency, Indonesia. Samples of the brain and synovial tissue were processed using hematoxylin-eosin dyes (HE). On histopathological examination, congestion, edema, mild infiltration of neutrophils and macrophages in the meningen, and ischemic neurona...
Zhaojun Wang1, Yang Zhou2 and Xinghua Song3*
...ular cavity in knee osteoarthritis treatment, and to analyze its effect on the prognosis of knee joint function. A total of 120 knee osteoarthritis patients admitted to our hospital from January 2019 to February 2020 were selected as the study subjects and randomly divided into control group and observation group (60 cases each). The control group was given injection of sodium hyaluronate in knuckle articular cavity, and the...
Heba S.S. Salem1, Hend M. Megahed2, Marwa M. Sarhan2, Maha M. El Alem3, Gehan N. Alagmy3*
...iotics for curing septic arthritis caused by Staphylococcus aureus (S. aureus). Thirsty-five naturally infected cases of rabbits with arthritis were screened for the prevalence of S. aureus as a causative agent. S. aureus was diagnosed in 40% of the examined cases via traditional culture methods and molecular confirmation using PCR. All tested S. aureus isolates were positive for virulence-associated genes (nuc, icaA, and Hl...
Caiyun Ma1, Hebao Wen1, Lu Li2, Gaofeng Liu1, Chunjing Wang1, Yu Guo1, Shiji Fang1, Hongyu Wang1* and Changqing Liu1*
...lage, the target of osteoarthritis (OA), contains renewable cartilage stem/progenitor cells (CSPCs) to maintain the tissue homeostasis. Compared with other adult stem cells, the self-renewal capacity and preference for chondrogenesis of resident CSPCs have propelled their exciting therapeutic prospects for cartilage repair. Tibetan mastiff, the ancestor of large breed dogs worldwide, represents a valuable model for human diseases. To our knowledge, this is the...
Farah Abid1,2, Mohammad Saleem1,3*, Tahir Maqbool4, Tania Ahmed Shakoori5, Faheem Hadi4, Tahir Muhammad4, Saira Aftab4, Yasir Hassan7 and Shabana Akhtar4,6*
...inflammation and also in arthritis by using animal model of rat. Thirty-six healthy wister rats were chosen for in vivo experiments and divided into six groups. Arthritis was induced in rats using Complete Freund’s Adjuvant (CFA) and treated with different concentrations of E-AM (250, 500 or 750 mg/kg), and with standard treatment, piroxicam (10 mg/kg). Antioxidant assays (superoxide dismutase and catalase) and histopa...
Azza M. El-Kattawy1, Tarek Abou Zed1, Randa Megahed1 and Mohammed El-Magd2*
...mmune disease rheumatoid arthritis depend mainly on synthetic anti-arthritis compounds that usually cause many adverse effects. The anti-arthritic effect of the hypocholesterolemic drug simvastatin (Sim) has been confirmed, however, its actual mechanism of action has not been investigated yet. Therefore, this study aimed to unveil the biochemical and molecular changes that accompany the application of Sim as anti-arthritic i...
Rana Mahmood Ahmad*, Orooba M.S. Ibrahim
...e the effect against Polyarthritis produced by complete Freund’s Adjuvants injected (S.c.) into the hind paw. The confirmation of the synthesis and characterization of ZnONPs was achieved through the utilization of a UV-spectrophotometer and SEM. For this purpose, eighteen adult male rats 200 ± 50 g at six months of age will be randomly divided into three groups, each containing six rats. Groups 2 and 3 were treated daily for 14 days from the day ...
Muhammad Usman1*, Aneela Zameer Durrani1, Nasir Mehmood2, Muhammad Hassan Saleem1 and Mamoona Chaudhry3
...cluding fever, anorexia, arthritis, lameness, and lymphadenopathy were used to declare the status of the disease at days zero, 7th, 14th, 21st, and 28th. Serum samples were also collected on the same days for determining C-reactive protein (CRP) values. The results of clinical biomarkers showed that doxycycline cured the dogs immediately when checked on the 7th day followed by amoxicillin on the 21st day; whereas dogs treated with azithromycin and clindamycin ...
Elie Brigitte Mawussi1*, Arnaud Koffi Assah2, Essozimna Abalo Kulo1
Ying Li, Peng Zhan, Qiang Wang and Dongfeng Chen*
...nts with varus knee osteoarthritis (VKO). The sample consisted of 110 patients with VKO who underwent total knee arthroplasty at Fujian hospital. The patients were divided into the lateral compartment cartilage abrasion group (n=30) and the lateral compartment cartilage non abrasion group (n=80) according to the lateral compartment cartilage status. The clinical data and laboratory indexes of patients were collected, and the risk factors of cartilage wear in l...
Sher Afgan1, Muhammad Asif2, Iqra Yaqoob3, Muhammad Latif4, Zureesha Sajid2, Kainat Akram3, Ghulam Mujtaba5, Manzoor Hussain6, Muhammad Farooq1, Mourad Ben Said7,8* and Furhan Iqbal3*
...gn: justify;">Rheumatoid arthritis (RA) is one of the most common autoimmune diseases in the world causing painful and swollen joints. RA is a progressive disease that can lead to various physical disabilities. The current study aimed to assess the association of the presence/absence of GSTM1, GSTT1 and single nucleotide polymorphism [SNP] (rs1695) in GSTP1 gene with RA. A cross-sectional study was conducted at Institute of Zoology, Bahauddin Zakariya Universi...
Awang Hazmi Awang-Junaidi1, Yeoh Boon Nie2, Siew Te Wong2, Nur Nabila Sarkawi3, Wafeq Mu’izzadin Khairul Anuar1, Siti Mariam Zainal Ariffin1*
...xamination revealed osteoarthritis in multiple sites of the appendicular joint, including the hip joint, stifle joint, elbow joint, and carpal joint, with bilateral involvement. Spondylosis deformans was observed in the cervical and thoracic vertebrae. The DJD changes include osteophyte formation, subchondral bone degradation, and joint remodelling. In conclusion, the findings provide valuable insights into the joint health of Bornean sun bear and highlight th...
Eslam Arafa1,2, Hanan M.F. Abdien1*, Mohamed Ali Zain El-Abideen3, Emad Diab2,4, Mahmoud Assad2,5, Mohamed Tarek3, Mohsen M.Z. El-Dimerdash1, Wael K. Elfeil1
...syndrome (RSS) and viral arthritis cases attributed to a novel strain of variant avian reovirus (ARV) that could bypass the protection conferred by traditional vaccines. Consequently, our study focused on identifying and characterizing the circulating ARV strain among various broiler flocks in Egypt. Out of 73 suspected reovirus examined samples, 23% tested positive for reovirus PCR at a fragment of 1088 base pairs using primers P1 and P4. These samples were c...
Muhammad Waqas*, Razia Bashir and Muhammad Arshad
...gn: justify;">Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that principally affects joints. Various diagnostic techniques are in use to detect RA based on the presence of auto-antibodies in patients’ blood like rheumatoid factor and anti-cyclic citrullinated peptides. We aimed to detect RF and anti-CCP antibodies for diagnostic evaluation of RA. RF was done by the latex agglutination method while anti-CCP test was performed on Abbot Ax...
