Yihong Tian, Yongmei Qi*, Sajid Naeem, Ke Gao and Yingmei Zhang*
... that spermidine induced autophagy by activating the LC3 conversion and p62 degradation at different concentrations and durations. However, inhibition of autophagy by 3-MA rescued the survival of Hela cells. This study demonstrated that the potential effect of spermidine on decreasing the survival of Hela cells is attributable to autophagy induction.
...
Ying Feng1 and Xuqun Pei2,*
...normalities and neuronal autophagy and apoptosis in patients with ischemic stroke and cognitive impairment. Glucose metabolism abnormalities and cognitive function in patients with ischemic stroke were detected by glucose tolerance test and neuropsychological test. Morris water maze test was used to detect learning and memory ability of MCAO model rats. RT-PCR and Western Blot method were used to detect the expression of autophagy
Jie Chen, Qinghua Qiu, Yanjiao Li, Xianghui Zhao, Lanjiao Xu, Xiaowen Xiong, Qingqi Wen, Mingren Qu and Kehui Ouyang*
...nces in energy levels on autophagy, adipogenic differentiation and fat metabolism between subcutaneous and visceral pre-adipocytes. C57BL/6J male mouse primary subcutaneous and visceral pre-adipocytes were isolated and in-vitro adipogenic differentiation was performed in high-glucose medium (4500 mg/L glucose, HGM) or low-glucose medium (1000 mg/L glucose, LGM). Lipid contents in adipocytes were determined by oil red-O staining. Autoph...
Chen Zhao, Lulu Ding, Ying Ye, Congying Kou, Haoran Xiao, Jing Zhu and Jicang Wang*
... mechanism of Cd-induced autophagy in the kidney and the antagonistic effect of Nar on Cd are still unclear. In this study, SD rats were treated with Cd and/or Nar to investigate the protective effect of Nar on Cd-induced toxicity. The rats were treated for 4 weeks. The histopathological observation, oxidative stress index and autophagy-related gene expression level were detected of rat kidneys. The results showed that Cd ca...
Ming-Hao Yu, Ming-Hui Gu, Xin Dai, Dao-Chen Wang and Sheng-Mei Yang*
...ced the level of ovarian autophagy by significantly increasing the expression of Beclin1 and LC3 proteins in the ovaries of the Brandt’s voles during sexual maturity. In short, tannic acid can promote the reproduction of Brandt’s voles by affecting the level of ovarian autophagy and improving the development of follicles. Tannins can boost the reproduction of Brandt’s voles....
Dynamic Effects of Ketogenic Diet on Autophagy and Cell Cycle in a Mouse Model of CT26+ Colon Cancer
Junrong Yang1, Ning Zhang1*, Muhammad Akram Khan2, Qingpeng Wang1*, Zhengping Wang1*, Quiqin Liu3, Lanjie Li3, Jun Han1, Abdul Asim Farooq4, Aayesha Riaz5 and Ruiyan Zhang1
...umors and contributes to autophagy and cell cycle progression of tumors. A ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet with documented anti-tumor effects. However, the mechanism of KD inhibiting colon cancer remains unclear. In this study, we investigated the molecular mechanism underlying the effects of KD on cell cycle and autophagy in colon tumor-bearing mice. Our results showed that com...
