Laila M. Fadda1, Nouf M. Al-Rasheed1, Iman H. Hasan1, Hanaa M. Ali2,3*, Nawal M. Al-Rasheed1,4, Musaed Al-Fayez5, Aly M. Ahmed5, Nada Almutlaq1, Nehal Qasem1 and Reem Khalaf1
...H), total protein, total bilirubin, hepatic glutathione (GSH), nitric oxide (NO), superoxide dismutase (SOD) and lipid peroxides (LP) levels were estimated. Moreover these biochemical parameters were confirmed by histopathological examination using hemotoxylin and eosin (H&E) and Mason trichrome stains (MTC). Immunohistochemical investigations for the expression of the proapoptotic protein (Bax) and the expression of macrosialin cluster of differentiation ...
Muhammad Kashif Maan1, Muhammad Arif Khan1, Shehla Gul Bokhari1, Muhammad Ijaz2, Hamid Akbar1, Sajid Umar 3 and Muhammad Luqman Sohail4,*
...sphatase, creatinine and bilirubin between the two groups. Heart rate, blood pressure and saturation of oxygen were decreased in both groups but this decline was significantly lesser (P<0.05) in isoflurane administered group compared to xylazine-ketamine administered group. Both xylazine-ketamine and isoflurane proved to be suitable anesthetic agents for successful ovariohysterectomy in rabbits. As injectable anesthesia caused significant effect on serum bi...
Tahir Abbas*1, Khawaja Raees Ahmad2, Asmatullah3, Khalid Pervaiz Lone4, Muhammad Ali Kanwal2, Sadia Suleman2
Reno-hepatic protective effects of Jambul against chromium induced anomalies in mice
...se (ALP), total protein, bilirubin, globulin, creatine and uric acid along with reduction of SGOT/SGPT, Blood Urea Nitrogen (BUN), urea and albumin as compared to control. Treatments with JFE after Cr+6 exposures significantly improved the hepatic and renal functional profiles possibly by partial liver rehabilitation and regeneration. The JFE significantly recovered the histopathological alterations in reno-hepatic tissue by free radicals scavenging and metal ...
Riffat Mehboob1*, Sami Ullah Mumtaz2, Zoya Manzoor3, Sajid Abaidullah2, Fridoon Jawad Ahmad1
Deranged biochemical and hematological profile of septicemia patients in Mayo hospital, Lahore
Hina Abrar1,2, S.N.H. Naqvi1,*, Muhammad Rashid Ahmed3, Asma Basharat Ali3 and Hina Yasin1,2
... ALT, ALP, γGT and bilirubin was significantly (p<0.05) increased in CBZ treated group as compared to control, whereas the hepatic parameters were significantly reduced in CBZ plus propranolol group. The histopathological examination reveals various features of hepatic architecture damage in CBZ treated group but the hepatic damage induced by CBZ was successfully ameliorated by propranolol. To conclude propranolol is effective in reducing the hepatoxi...
Yang Liu1, Jing-xin Mao2, Xiao-dong Wei2, Man Yi2, Xiao-long Zhang2, Ke Zheng3, Xian-xin Chen4, Guo-Ze Wang5 and Bing-bo Chen1,*
...lus BFA group. The total bilirubin decreased significantly (P<0.05) both in lactobacillus BFA and Bacillus BFA group. Total weight gain and daily gain were increased in mixed fermentation BFA group significantly than the control group (P<0.05). For feed conversion rates in each group, the mixed fermentation BFA group had the highest feed efficiency, increased by 10.04% than the control group, followed by the yeast BFA group, with an increase by 4.14%. Th...
Chaman Ara1*, Asmatullah1, Sehrish Kanwa1, Asma Chaudhary2, Ayesha Siddiqua1
...ne phosphatase (ALP) and bilirubin was observed in blood plasma. Urea level showed a remarkable decrease, whereas creatinine level increased but not significantly. Histological examinations exhibited pyknosis, necrosis, vacuolations, increased sinusoidal spaces, karyomegaly, glomerulosclerosis, glomerulonephritis, epithelium degeneration, spermatocytes exfoliation, tubular degeneration and aspermia in liver, kidney and testis respectively. Levofloxacin causes ...
Chaman Ara1*, Asmatullah1, Zainab Riaz1, Memoona1, Asma Chaudhary2, Shagufta Andleeb2
... significant increase in bilirubin levels in BP group. Significant raised patterns were recorded for urea and creatinine in BP intoxicated mice against control. Histological defects observed were necrosis, pyknosis, increased sinosuidal spaces, portal hypertension, glomerulosclerosis, abnormal vascular pole in liver and kidney respectively. But when turmeric powder was coadministered with BP, these damages were reversed to a great extent. So, this study has pr...
Mumtaz Ali Khan1, Sher Bahadar Khan2, Shakoor Ahmad2, Irshad Ahmad3, Kashif Prince1*, Ghazunfar Rashid1, Mahboob Ali1, Imdad Ullah Khan4, Asad Ullah5, Naimat Ullah4, Muhammad Shoaib2 and Said Sajjad Ali Shah2
...l volume (PCV) and total bilirubin levels increased significantly (P<0.05) in sheep infected with Clostridium perfringens type A. Sheep infected with Clostridium perfringens type B and type D showed significant (P<0.05) decreases in erythrocytes counts (RBC) and hemoglobin levels while the mean WBC, platelets, packet cell volume, serum creatinine, bilirubin, liver enzymes, total, glucose and urea in blood...
Yasir Sharif1, Saba Irshad1*, Ammara Muazzam1, Muhammad Hamza Tariq1, Ambreen Kanwal1, Sana Rasheed1, Mabel Baxter Dalrymple2 and Anam Tariq1
....77±18.223U/L and bilirubin 1.02±0.139mg/dL. CBC of control group revealed that all of the studied parameters were normal in them and BTM patients showed significant deviation from control in both hematological and hepatic profile (P < 0.05). Examination for secondary complications revealed that Pallor sign was observed in 79.6% of patients, followed by splenomegaly (64.9%) and hepatomegaly (9%). As far as the control group is concerned no com...
Syed Shahid Imran Bukhari1*, Nusrat Jahan2, Muhammad Khalil Ahmed Khan3, Mariam Zaheer1, Sabir Javed1
...as effective in reducing bilirubin (0.67±0.15), SGPT (35.67±2.03), SGOT (127.67±4.67) and alkaline phosphatase (86.33±1.86) compared to their corresponding control group values. A. barbadensis (400mg/kg) reduced cholesterol (78.00±2.08), triglycerides (83.67±3.28), HDL cholesterol (49.33.67±2.33) and LDL cholesterol (61.67±3.84). Pancreatic and hepatic sections from diabetic induced group 2 mice showed va...
Ahmed Mohamed Elmahdy1*, Naglaa Mohammed Alkalamawy2
...nsferase (GGT) and total bilirubin, also the levels of Cholesterol, Triglycerides, HDL-cholesterol, LDL- cholesterol and VLDL-cholesterol were also estimated. The degree of renal protection was measured using creatinine, urea, sodium, potassium, also the levels of total protein, Albumin and Globulin were quantitated also the histo-pathological examination of the liver, kidneys were done. Results showed that the administration of O.M. extract restored the sever...
Hussein Jabar Jasim1*, Amer Murhum Al-Amery2
...eases in the serum total bilirubin, creatinine, and active serum enzymes ALT, AST, ALP, and GGT. In contrast, the serum total albumin showed a significant decrease in infected buffaloes. Moreover, the results of the gross pathological examination revealed that cirrhosis and paleness of the liver with multiple abscesses appearing as pale necrotic areas, as well as thickness and calcification with fibrinous exudates of bile ducts, were the most frequent gross le...
Anhar Ibrahim Elhanafy*, Amr Mohamed Mousa, Amaal Mohamed Kamal
...transferase, serum total bilirubin, direct bilirubin and in direct bilirubin, serum creatinine, urea content, serum total cholesterol, triglycerides, and low-density lipoprotein, and vice versa regarding the high-density lipoprotein concentration was observed, compared to control. Moreover, BV caused a decrement in malondialdehyde and nitric oxide levels whilst it enhanced GPx activity, S...
Saba Yasin, Kausar Imran, Komal Mukhtar, Muhammad Amir Iqbal and Nabila Roohi*
...sphatase (ALP) and total bilirubin in painters as compared to control group. However, Aspartate Aminotransferae (AST) was mildly increased in painters. Creatinine and urea exhibited significant elevation in painters as compared to controls. Conclusively, long-term exposure to paints and associated chemicals may lead to severe hepatic and renal damages....
Fatimah A. Al-Saeed
...rs (ALT, AST, ALP, total bilirubin, creatinine (Cr), BUN, uric acid, MDA, IL-6 and TNF-α) were significantly increased in rats of the second group. Moreover, the levels of total protein, albumin and CAT were statistically declined. The O. oleaster leaves’ extract could nearly normalize those blood parameters for protection against Cd toxicity. It might be concluded from this study that the protective effect of O. oleaster leaves extract against Cd ...
Tehreem Iqbal1, Roheela Yasmeen1* and Faheem Hafeez2
...of the rat. Liver (Total bilirubin, alkaline phosphate test, Lactate dehydrogenase, and alanine amino transferase) and kidney (Blood Urea Nitrogen, Creatinine, and Uric acid) biomarkers were assessed. The highest levels of ALT and ALP were linked to liver injury and a higher weight in the liver were observed in BPA treated rats as compared to the control group. Similarly, an increase in blood parameters were recorded in BPA treated rats followed by post -treat...
Nusrat Habiullah1*, Shah Nawaz Kumbar1, Fahmida Parveen Samo1, Shamusuddin Bughio2, Asghar Ali Kamboh3, Burirah Rehman Talpur1
...utamyltransferase (GGT), bilirubin, albumin, uric acid and creatinine. After necropsy examination, the liver and kidney samples were collected for gross and histopathological examination. The mild clinical signs like reduced feed and water intake, and weight loss in group C, D, E and F was noted; whereas diarrhea, muscular tremors, and lethargy were observed in group C and D. Significantly increased (p <0.05) GGT, bilirubin
Babi Kyi Soe1*, Toe Win Naing2, Su Lai Yee Mon1, Nay Chi Nway3, Hiroshi Sato4
... as ALT, AST, GGT, total bilirubin, and blood urea nitrogen (BUN) occurred by blood biochemical analysis, whereas total protein and albumin were low. To our best, this study is the first molecular evidence for the presence of Anaplasma marginale infection in cattle in Myanmar, with a sequence similarity range between 98.8 and 100%. By understanding one of the major tick-borne pathogens (TBPs) in Myanmar, possible control measures might be implemented not only ...
Muhammad Azhar1,2, Rida Ahmad3*, Bushra Nisar Khan3 and Zahra Hussain3
...nine transaminase (ALT), bilirubin, creatinine, blood urea nitrogen (BUN) were determined. Further, different biological, analytical and operational factors which impose significant effects on hematochemical factors were also considered to rationalize the results. Most of the values were in accordance with the mean values published in the literature, but values of few parameters e.g., hematocrit, platelet, AST, ALT, ALP and blood urea nitrogen were found diffe...
Huda K. Khassaf1*, Zainab A.H. Al-Mousawi1, Sawsan A. Ali2, Anwar Nather Seiwan3
...e estimated. Also, total bilirubin (TB), Na+, K+, CL- and Ca+2 were measured. A statistical analysis of the thyroid gland tissue’s histological alterations was conducted. According to the findings, rats that got both SAL and ALA had higher levels of serum thyroxin T4, Free T3, and Free T4 than rats that did not get alA (p≤0.05). As well as decreased total bilirubin, Na+, and Ca+2 levels and increased K+ and Cl- leve...
Marah Salim Hameed1, Raad Mahmood Hussein Al Zubaidi2, Ali Ibrahim Ali Al-Ezzy3*
...um cortisol, total serum bilirubin, liver enzymes (ALT, AST, and ALP) were determined. Significant variation was reported in serum cholesterol between ethanolic extract vs control. Significant variation in total Serum albumin was reported between aqueous extract vs ethanolic group. Significant variation was reported in total Serum bilirubin between groups (aqueous extract vs control). No significant variation was reported in...
Mohammed Mijbas Mohammed Alomari1, Nawar Jasim Alsalih2*, Samir Sabaa Raheem2, Mohenned Alsaadawi2, Ali Mosa Rashid Al-Yasari3
... urea, creatinine, total bilirubin, circulating immune complexes, the activity of alanine and aspartic aminotransferases, α-amylase in blood serum, erythrocytes, leukocytes, T- and B-lymphocytes, O-cells, and T-helpers. From this study concluded the treating sick dogs, positive changes occurred, which are characterized by an improvement in the general clinical condition , normalization of the concentration of hemoglobin in the blood, total protein, album...
Abdul Ghaffar1*, Kashfa Akram1, Habiba Jamil1, Riaz Hussain2, Ghulam Abbas3, Fozia Afzal4, Ahrar Khan5,6, Rabia Tahir7, Muhammad Ahmad Chishti1 and Shahnaz Rashid3
...els of urea, creatinine, bilirubin, alanine transaminase (ALT), alkaline phosphatase, very low-density lipoprotein (VLDL), cholesterol, and triglycerides in exposed workers. Conversely, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), creatine phosphokinase, and serum minerals were notably reduced in exposed workers compared to unexposed counterparts. Prolonged pesticide exposure induces oxidative stress, evidenced by ...
Tahani Ahmad Al-Matrafi1, Zuhair M. Mohammedsaleh2, Mamdoh S. Moawadh2, Waheeb S. Aggad3, Rawabi Mohamed almuhimed4, Zamzam Alhuwaymil5, Aishah E Albalawi6, Ifat Alsharif7, Hailah M. Almohaimeed8, Fatima S. Alaryani9 and Mona H. Soliman10,11*
...rs (ALT, AST, ALP, total bilirubin, and total protein in blood serums), hepatic antioxidants (SOD, CAT, GSH, and GPx in liver homogenate), and inflammatory markers (IL-6, TNF-α, COX2), along with other liver biomarkers. Histopathological alterations in the liver were evaluated using Hematoxylin and Eosin staining. The leaf extracts effectively restored liver function indicators and hepatic antioxidants to normal levels, demonstrating a significant improv...
Abdul Ghaffar1*, Ayesha Maqsood1, Riaz Hussain2, Ghulam Abbas3, Rabia Tahir4, Habiba Jamil1, Fozia Afzal5, Ahrar Khan6,7, Muhammad Ahmad Chishti1, Shahnaz Rashid3, Aliya Noreen8, Kashfa Akram1 and Maria Niaz1
...ucose, urea, creatinine, bilirubin, ALT, and ALP, were analyzed. Multiple comparisons were made with different diseases, revealing variations between pesticide-exposed and unexposed individuals. The comet assay method was utilized to observe damaged DNA in pesticide-exposed individuals and compare its prevalence across different age groups. The findings indicated an increase in the rate of DNA damage with age. Highly damaged cells exhibited a greater tail leng...
Hina Abrar1*, Hina Yasin1, Hira Naeem2, Rabia Bushra1, Shaukat Mahmood2 and Kaneez Fatima3
...sferase (γ-GT) and bilirubin (BRB) were measured and compared with the normal values. Additionally, histological examination was done through micrometry and scanning electron microscopy (SEM) to estimate the intensity of hepatotoxicity induced by PHY and PHY with PRL. Animals received PHY alone treatment showed a significant elevation of liver enzymes than control and combination. Conversely, the lower level of serum ALT, ALP, γGT and BRB were foun...
Aamir Khan Awan1, Nighat Sultana1*, Rahmat Ali Khan2, Rifhat Sultana3,
Umm-e-Kalsoom1, Fayaz Ahmed Sahibzada4, Rifat Ullah Khan5, Naimat Ullah Khan6, Nazir Ahmad Khan7, Syed Haider Zaman8, Mir Sadiq Shah9 and Assar Ali Shah10*
...nsity lipoprotein, total bilirubin, alkaline phosphatase, alanine aminotransferase, urea, serum creatinine and total proteins were significantly (P<0.05) decreased in response to oral dosing of three varieties of P. granatum peel methanolic and aqueous extracts which were comparable to healthy control. Moreover, the aqueous extracts and wild P. grantaum were more effective than methanolic extracts and other species against hyperglycemia and biochemical prof...
Kamal Ahmed El-Shazly1, Amira Abd El-Latif1, Nagwa Elhawary2, Asmaa F. Alswaf1, Foad Farrag3, Samy Sayed4, Mohamed El-Sharnouby5 and Mustafa Shukry6*
...ic, ALP, ALT, AST, total bilirubin, creatinine, urea, uric acid, and MDA level, the body weight significally reduction, weight gain in the body, feed consumption, hematological parameters, lymphocytes%, cholesterol level, and Catalase enzyme activity. These results followed the histopathological findings. Treatment with the tested drugs improved all the tested parameters. Still, the control of coccidiosis caused by Eimeria tenell is highly effective by combina...
Monira Sultana1, Md. Shohel Al Faruk2*
...vity (1.01), ketone (-), bilirubin (-), blood (+) report shows that dark color urine have strong odor and blood found in urine. Peripheral lymp-nodes were normal. Ultrasound revealed the thickness of the wall of urinary bladder and increase hyper-tonic contents. In X-ray (Figure 4) it was seen distended urinary bladder, ureteral obstruction and vesicoureteral reflux were seen. Biochemical report (Table 2) was shows that increase the level of blood urea nitroge...
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Application of Various Diagnostic and Therapeutic Approaches for Detection of a Hemorrhagic Cystitis in a Persian Cat
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