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Antioxidant and Antidiabetic Potentials of Punica granatum Peel Extracts in Alloxan-Induced Diabetic Albino Rats

Antioxidant and Antidiabetic Potentials of Punica granatum Peel Extracts in Alloxan-Induced Diabetic Albino Rats

Aamir Khan Awan1, Nighat Sultana1*, Rahmat Ali Khan2, Rifhat Sultana3
Umm-e-Kalsoom1, Fayaz Ahmed Sahibzada4, Rifat Ullah Khan5, Naimat Ullah Khan6, Nazir Ahmad Khan7, Syed Haider Zaman8, Mir Sadiq Shah9 and Assar Ali Shah10*

1Department of Biochemistry, Hazara University, Mansehra, Khyber Pakhtunkhwa, Pakistan.
2Department of Biotechnology, University of Science and Technology, Bannu, Khyber Pakhtunkhwa Pakistan.
3Department of Chemistry, Hazara University Mansehra, Khyber Pakhtunkhwa, Pakistan.
4Department of Clinical Nutrition AIMS, Hospital, Muzaffarabad, Pakistan.
5College of Veterinary Science, Faculty of Animal Husbandry and Veterinary Sciences, The University of Agriculture, Peshawar, Pakistan.
6College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University, Mardan, Pakistan.
7Department of Animal Nutrition, The University of Agriculture Peshawar, 25130, KP, Pakistan.
8Department of Clinical sciences, KBCMA, College of Veterinary and Animal sciences, Narowal sub-campus University of Veterinary and Animal sciences Lahore, Pakistan.
9Department of Zoology, University of Science and Technology, Bannu, Khyber Pakhtunkhwa, Pakistan.
10Tropical Feed Resources Research and Development Center (TROFREC), Department of Animal Science, Faculty of Agriculture, Khon Kaen University, Khon Kaen 40002, Thailand.
 
*      Corresponding author: [email protected], [email protected]

ABSTRACT

The peel/rind of Punica granatum is approximately 60% of the total fruit weight which is generally wasted every year, although, it is known to have a variety of medicinal benefits. The present study was conducted to find the antioxidant activity and antidiabetic potentials of P. granatum peels extracts in alloxan-induced diabetic albino rats. The diabetes was induced in albino rats using alloxan at the concentration of 150 mg kg-1 body weight. After 15 days, the treated groups with glabinclemide and different varieties of methanolic and aqueous extracts showed a significant (P<0.05) decrease in the blood glucose level as compared to diabetic control while slight differences were seen in body weight. The total cholesterol, triglycerides, and low-density lipoprotein, total bilirubin, alkaline phosphatase, alanine aminotransferase, urea, serum creatinine and total proteins were significantly (P<0.05) decreased in response to oral dosing of three varieties of P. granatum peel methanolic and aqueous extracts which were comparable to healthy control. Moreover, the aqueous extracts and wild P. grantaum were more effective than methanolic extracts and other species against hyperglycemia and biochemical profiles of treated rats. It was concluded that the extracts of peels of P. granatum possess significant antihyperglycemic and antihyperlipidemic potentials due to presence of phytochemical and have no side effects. Based on the outcome of the study it can be recommended that the peel of P. granatum can be further used for the development of antidiabetic drugs or in folk medicines traditionally to treat the diabetes.

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Pakistan Journal of Zoology

October

Pakistan J. Zool., Vol. 56, Iss. 5, pp. 2001-2500

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