Xuya Zhou1, Ying Liu1, Deqin Xu1, Jie Bao1, Yaru Cao2 and Yong Jin3*
...2 inhibitors: rofecoxib, celecoxib. This study was aimed to find out whether unification of two drugs would increase cardiovascular side effects. Type 2 diabetic rat model was induced through feeding with fodder containing high sugar and lipid and intraperitoneal injection of streptozotocin. The adjuvant-induced arthritis model was established by Paraffin/BCG. We used western blot to explore the protein expression levels of COX-2 and cytochrome P450 (CYP) 4A1....
Hafiz Adnan Ahmad1,2*, Muhammad Aslam2, Salman Gul2, Tariq Mehmood2 and Munawar Ali Munawar2
...tial than standard drugs celecoxib and indomethacin. While the anti-inflammation profile of compounds 4h, 4e and 4f during in vivo screening was also comparable to celecoxib and indomethacin. The structure-activity relationship (SAR) was also discussed with the reference of substituent nature. Present results showed that newly synthesized hybrids have significant anti-inflammatory potential and might be played an important r...
Zuhair M. Mohammedsaleh1*, Mamdoh S. Moawadh1, Fayez M. Saleh2, Mohammed M. Jalal1, Abdulaziz S Al-Otaibi1, Nizar H. Saeedi1, Rathinasamy Baskaran3, Chih-Yang Huang4 and V. Bharath Kumar5*
...the inhibitory effect of celecoxib (CXB), cisplatin (Cis) and the combination of CXB and Cis and to explore the potential molecular mechanisms involved in oral cancer cells (OC-3 and SCC-9). MTT assay was used to check the cell viability, cell migration and invasion was performed to evaluate the metastasis and western blot to check the protein expression. The results showed that the combination of CXB and Cis synergistically inhibited cell proliferation, migra...
