Ginsenoside Rh2 Reduces Inflammation of Ulcerative Colitis via Elevating microRNA-30a-5p
Ginsenoside Rh2 Reduces Inflammation of Ulcerative Colitis via Elevating microRNA-30a-5p
Suanyuan Zhang, Qing Ji, Xinglong Wu, Jinjing Wang, Jin Yao, Chengfang Li, Xiaorong Yang, Na Tan, Jing Yang and Hong Zheng*
ABSTRACT
Ulcerative colitis (UC) is a kind of chronic inflammatory bowel disease, closely related to colon cancer. Ginsenoside Rh2 (GRh2) is a rare protopanaxadiol type triterpene saponins in ginseng, which has anti-inflammatory/cancer/diabetic impacts. To investigate the molecular mechanism in which GRh2 reduced inflammation of UC via upregulating microRNA (miR)-30a-5p, we detected miR-30a-5p in the tissues and serum of patients with active UC and in NCM460 cells after dextran sulfate sodium (DSS) treatment. Inflammation factors, nuclear factor-κB (NF-κB) and p65, were detected in NCM460 cells introduced with disparate concentrations of GRh2 after DSS treatment or transfection. We found that GRh2 increased expressionlevels of miR-30a-5p to inhibit inflammation and promote to advancement of NCM460 cell. In conclusion, enhancive miR-30a-5p further elevated GRh2’s repression UC’s progression. GRh2 drives miR-30a-5p to repress inflammation, NF-κB pathway and cell advancement, thereby mitigating UC.
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