Expression of Aquaporin-1 and Endothelin-1 in Children with Congenital Hydronephrosis
Expression of Aquaporin-1 and Endothelin-1 in Children with Congenital Hydronephrosis
Jinjian Ma1, Zhaokang Wang2 and Hong Liu3*
ABSTRACT
The objective of this study was to analyze the expression of aquaporin-1 (AQP-1) and endothelin-1 (ET-1) in children with congenital hydronephrosis. A study group consisted of 52 children who were admitted to our hospital from August 2021 to August 2022 and diagnosed with congenital pyelonephric junction stenosis (UPJO) leading to hydronephrosis through imaging examination. At the same time, 20 hospitalized children without hydronephrosis were enrolled as the control group. Record two sets of urine β Compare the protein expression and mRNA expression of AQP-1 and ET-1 in 2-MG, serum creatinine (Scr), and serum Ccr, analyze the expression of AQP-1 and ET-1 mRNA at different levels, and analyze the correlation between AQP-1 and ET-1. Compared with the control group, the expression of AQP-1 protein in the study group was lower, but the expression of ET-1 protein in the study group was higher than that in the control group; the expression of AQP-1 mRNA in the control group was higher than that in the study group, and the expression of ET-1 mRNA in the control group was significantly lower than that in the study group. In children with congenital hydronephrosis, the expression of AQP-1 protein and AQP-1 mRNA is low, while the expression of ET-1 protein and ET-1 mRNA is high, showing a negative correlation (r=0.365, P=-0.002). It was concluded that AQP-1 and ET-1 proteins are involved in the progression of congenital hydronephrosis and may be potential biomarkers for diagnosing the condition of congenital hydronephrosis.
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