Afsheen Masood1*, Rubab Musarrat2, Shama Mazahir3 and Adeela Ashraf4
...parents of children with leukemia with that of normal cohort. Case control study design was used. The sample consisted of N=120 parents out of which n=60 were the parents of children with leukemia and n=60 were the parents of normal children, , taken as normal cohort and drawn through non-probability purposive sampling procedure. Both cohorts were matched on the basis of the age and income level of the parents. Quality of Li...
Munir Ahmad1, Aisha Hameed2*, Saba Khaliq3, Hamid Saeed Malik4 and Shahida Mohsin5
...b> | Acute lymphoblastic leukemia (ALL) is the most common malignant tumor in children and forms a major fraction of childhood malignancies in the developed countries. Numerous chromosomal aberrations have been observed in ALL including translocations which result in the production of fusion genes (BCR-ABL, TEL-AML1, and MLL-AF4). These chromosomal rearrangements have great prognostic and therapeutic significance. Amongst these, TEL-AML1 fusion gene rep...
In-vitro Anticancer Activity of Copper (II) and Zinc (II) Complexes with Derived Schiff Base Ligands
Qaisar Jamal1,Salman Ahmad1, Nazma Habib Khan1, Sobia Wahid1, Muhammad Ikram2, Sadia Rehman2, Syed Basit Rasheed1 and Akram Shah1,*
...I)), against human THP-1 leukemia cell line in-relation to miltefosine (standard chemotherapy). Mean % inhibition for NM-3 against THP-1 was higher than NM-4, although both were less effective than miltefosine. IC50 for miltefosine, NM-3 and NM-4 against THP-1was 0.000347µM, 44.9µM and 119µM; whereas, their cytotoxicity was 72.26µM, 255µM and 293.8µM, respectively against peripheral blood lymphocytes. Based on the...
Samiah Shahid1,Jawaria Shaheen1, Wajeehah Shahid2, M. Waheed Akhtar1,3 and Saima Sadaf1,*
Rao Muhammad Ramiz1, Arfan Ahmad2*, Aamir Ghafoor2, Muhammad Avais3, Qurat-ul-Ain1 and Muhammad Zahid Iqbal3
...ont-size: small;">Bovine leukemia virus (BLV) is the cause of enzootic bovine leukosis and has worldwide distribution. This is study reports presence and genetic diversity of BLV in cattle of two districts of Punjab, Pakistan. Blood samples (n=400) taken from local (n=200) and exotic (n=200) breeds of cattle were processed for complete blood count. Based on lymphocyte counts, samples were divided into two groups (A, lymphocytosis, B, normal lymphocytes) and te...
Ahmed Alazzouni1, Ashraf Al-Brakati2,*, Sherif Rabie1, Mohamed Gabry1 and Basmaa Hassan1
...h after the induction of leukemia. We found that the extracts ameliorated most histopathological changes in MLNs and spleens in rats exposed to benzene, restoring normal mast cell counts and elastic fiber area percent in a benzene-induced leukaemia model. To conclude Moringa oleifera, curcumin, and green tea extracts could be used as natural chemotherapeutic agents and as adjuvants to ameliorate histopathological changes associated with <...
Chemoprotective Effect of Daphnetin against Benzene Induced Leukemia Cancer via Alteration of CYP2E1
Junling Liu, Chen Sun, Qiao Yu, Yanzhi Liang, Shanshan Lin and Meng Tian*
... Available treatment for leukemia are chemotherapy, allogeneic cell transplantation and radiation therapy with side effects. Due to side effect linked with the treatment, medicinal herbs treatment having the more attraction to treat the leukemia. The current study was to scrutinize the anti-leukemic effect of daphnetin against benzene induced leukemia in rats and explores the underlying me...
Hafiz Muhammad Arsalan1, Amina Arif1 and Muhammad Khalil Ahmad Khan2*
...ustify;">Chronic myeloid leukemia (CML) is a chronic proliferating cancer of bone marrow presently treated with BCR-ABL tyrosine kinase inhibitors (TKI). Within interacellular system, increased reactive oxygen species (ROS) production in response to antioxidant (AOX) defense systems lead to oxidative stress (OS). Our study aimed at biochemical profiling of CML patients in response to imatinib or nilotinib therapeutic drugs. Fresh venous blood sample (10 mL) of...
Musaad A. Al-Dubaib
...s were tested for bovine leukemia virus (BLV) antibodies for different animal species. Agar gel immunodiffusion was carried out using commercial diagnostic reagents. All samples of herds having positive cases with immunodiffusion were tested by ELISA. Positive cases were recorded among samples of the Holstein cattle with both serological tests. Prevalence rates differed from one farm to another and with both serological tests. With agar gel immunodiffusion, th...
Yanhong Zhao, Bo Guo, Lin Fu, Biao Liu and Jing Xue*
...al (PI) of lymphoma cell leukemia (LCL), and then provide scientific data for clinical typing of lymph node cell leukemia. The BMFC typing and PI data of 86 patients with LCL admitted to our hospital from January 2018 to January 2022 were retrospectively analyzed to compare the BMFC typing and PI expression, and investigate the differences in PI results among patients with different BMFC typing. There were significant differ...
Rehana Yasmin1,2, Rashda Abbasi2*, Tariq Saeed2, Madiha Sadiq2, Nuzhat Yasmeen3, Muhammad Iqbal4, A. Khuzaim Alzahrani5, Nadeem Kizilbash5, Ugur Bilge6, Nafees Ahmad2 and Sajid Malik1*
...typic characteristics of leukemia subtypes were investigated in Pakistani population. A total of 1500 subjects, including 616 patients and 884 controls were recruited through a retrospective cross-sectional sampling design. Descriptive summaries were generated, and risk factors were analyzed through logistic regression. We identified Pathan ethnicity (OR=2.85; 95%CI=2.29-3.54), no formal education (OR=3.36; 95%CI=2.62-4.32), poor diet (OR=2.34; 95%CI=1.79-3.06...
