Search for Prostate

Effect of Variable Kisspeptin Doses on Prostatic Citric Acid Levels in Male Mice

Faiqah Ramzan*¹ and Muhammad Haris Ramzan²

...ized and secreted by the prostate gland. Its synthesis is regulated by androgens. As, dose dependent degeneration of prostate gland has been described following intraperitoneal kisspeptin treatment. However, effects of kisspeptin administration on the levels of prostatic citric acid remain elusive till date. The present study, therefore, addresses the effects of 12 day administration of kisspeptin on prostatic citric acid le...

Antimicrobial and Anti-Prostate Cancer Activity of Turmeric (Curcuma longa L.) and Black Pepper (Piper nigrum L.) used in Typical Pakistani Cuisine

Saba Irshad^1,*, Ayesha Ashfaq¹, Ammara Muazzam¹ and Abida Yasmeen²

Possible Antiproliferative Effect of Tolfenamic Acid on Human LNCaP Prostate Cancer Cell Lines

Rıfat Ertekin¹*, Mete Ozkurt¹, Gokhan Kus² and Selda Kabadere¹

...androgen-sensitive human prostate cancer cell line (LNCaP). In our study, 1, 5, 10, 25, 50, and 100 μM doses of TA were applied to T-98G and LNCaP cell lines for periods of 24 and 48 h. Subsequent cell vitality was tested with MTT Atest. The effective doses were analysed by flow cytometry and real-time PCR techniques. MTT spectrophotometric tests showed no significant effects on the survival rate of T-98G cells in 24 and 48 h. Therefore, T-98G cells were no...

Rab21, an Endocytic Rab GTPase, is Involved in Drug Resistance in Prostate Cancer Cells

Maryam Yousaf¹, Naveed Shahzad², Zeeshan Mutahir¹ and Moazzam Ali¹*

..., mediated resistance in prostate cancer cells. Drug sensitive (PC-3/Wt) and epirubicin resistant (PC-3/Res) prostate cancer cell lines were used in this study. Our data revealed that PC-3/Res cells had high expression of MRP-1 mRNA and protein in comparison with PC-3/Wt cells. MRP-1 was found distributed between intracellular and cell surface pools in PC-3/Res cells and was capable of drug efflux as shown by doxorubicin and...

Effect of SSAT on the Proliferation and Apoptosis of Prostate Cancer Cells via Regulation of Akt, GSK-3β and β-catenin Expression

Xian Zhang¹, Erjiang Lin¹, Shizhe Hong¹ and Zhengjie Zhu²*

...eration and apoptosis of prostate cancer LNCaP cells under hypoxic conditions. Prostate cancer LNCaP cells were transfected with the eukaryotic expression plasmid pcDNA3.1 (D)/V5-His-SSAT, and cultured at 1% oxygen concentration. Western blotting was used to detect expression of SSAT, Akt, GSK-3β and β-catenin proteins; and flow cytometry was used to detect cell apoptosis rate and mortality rate. SSAT was successfu...

Studies on the Occurrence of Prostate Cancer in Gujrat, Punjab, Pakistan and its Association with Testosterone Level

Kanwal Nisa¹, Sadia Roshan¹, Shazia Shamas^1,2*, Raheela Atta Mustafa³, Shamaila Irum¹, Kalsoom Sughra⁴ and Memoona Iqbal¹

...els of testosterone with prostate cancer patients by the evaluation of a tumor marker Prostate-specific antigen (PSA). Prevalence was recorded in Gujrat, Punjab, Pakistan. Blood samples of normal and prostate cancer males were taken from Gujrat, Punjab, Pakistan. Information including age, marital status, smoking, Prostate-specific antigen (PSA), testost...

The Levels of Prostate Specific Antigen and Leptin Hormone in Patients with Prostate Cancer

Nesreen Ahmed Nasser1, Anas H. Sadek2, Bayadir Abdulhussein Mahmeed3, Osama Akram Mohsein4*

...pic, although MRI scans, prostate tissue biopsies, and prostate-specific antigen (PSA) testing are the main diagnostic methods. Aims of the study: Estimating the levels of prostate cancer antigen and leptin in patients with prostate cancer and their role in the development of the disease. Methodology; The study included 35 men suffering from

Estimation Role of Spirulina Platensis Extract in Treatment Experimentally Infertility caused by Metronidazole in Rats

Fatima Aziz Mahdi Al-Badry*

...mental period was ended, prostate was weighted, fertility parameters were studied by assessment of concentration and sperm malformations, fertility index, sex hormones and histological sections of sperm were prepared. The results revealed show that metronidazole intake causes a decline in prostate and body weight, reduction of sperm, fertility index and sex hormones (LH,FSH and Testosterone) with increasing of sperm abnormal...

Histopathological and PCNA-Based Immunohistochemical Assessment of Pumpkin and Grape Seed Extracts in Protecting Male Rat Accessory Glands Under Chemotherapeutic Stress

Ibrahim Elmaghraby¹, Zeinab Said², Marwa Darweish¹, Doaa Galal El-Sahra³ and Ahmed Ibrahim El-Nemr⁴*

...The seminal vesicles and prostate exhibited marked atrophy, decreased secretory material, epithelial hyperplasia, and necrosis, accompanied by significant organ weight reduction and diminished PCNA immunoexpression. Pretreatment with either PSE or GSE significantly ameliorated these CP-induced alterations, restored organ weights, and enhanced PCNA immunoexpression. Both PSE and GSE demonstrate promising protective potential against CP-induced reproductive toxi...

Effect of TRAF6 on Proliferation of Prostate Transitional Zone and Peripheral Zone Cells

Yulin Zeng

...g proliferation (Pro) of prostate transitional zone (TZ) and peripheral zone (PZ) cells by activating the insulin-like growth factor 1-protein kinase/mammalian target of rapamycin (IGF1-Akt/mTOR) signaling, providing a research basis for benign prostatic hyperplasia (BPH) therapy. In vitro proliferative prostate tissue specimens from patients with BPH were collected and classified into PZ and TZ tissues. A TRAF6 interference...