Estimation Role of Spirulina Platensis Extract in Treatment Experimentally Infertility caused by Metronidazole in Rats
Estimation Role of Spirulina Platensis Extract in Treatment Experimentally Infertility caused by Metronidazole in Rats
Fatima Aziz Mahdi Al-Badry*
ABSTRACT
The indiscriminate use of drugs poses a significant health risk. So, the aim of the study is to evaluate the harmful effects of metronidazole in parameters infertility of male reproductive system and treatment by Spirulina platensis extract. Thirty two of male rats were used. They were divided into four groups (8/each). The first group administrated distilled water as control group. The second group was received oral dose of metronidazole (18 mg/200 body weight /day) while the third and fourth groups were treated with ethanolic extract of Spirulina platensis after receiving metronidazole for (one and two months) respectively. The dose of drug and ethanolic extract was taken orally. When experimental period was ended, prostate was weighted, fertility parameters were studied by assessment of concentration and sperm malformations, fertility index, sex hormones and histological sections of sperm were prepared. The results revealed show that metronidazole intake causes a decline in prostate and body weight, reduction of sperm, fertility index and sex hormones (LH,FSH and Testosterone) with increasing of sperm abnormalities, while all previous indicators of fertility were increased with reduction of abnormal sperm by receiving the ethanolic extract of algae (Spirulina platensis). In addition, morphological and structural damages of sperm were involved global, elliptical, lacking of head with quirky and absence of tail as well as sever abnormalities and breakdown of sperm. The conclusion showed that it is terminated metronidazole exposure causes induction of infertility and treated by ethanolic extract of Spirulina platensis.
Keywords | Metronidazole, Infertility, Spirulina platensis, Sperm, Testosterone, Rats
To share on other social networks, click on any share button. What are these?
