Promy Virk
.../i> seed extract (TN) on streptozotocin (70 mg/kg) induced diabetic rats was assessed for a period of 7 weeks. Metformin was used as a standard drug. The results of Zetasizer and Transmission and Scanning Electron Microscopy images showed the presence of spherical to irregularly shaped green gold and silver (Au/Ag) nanopcomposite with an average size of 73.18 nm with polydispersity. A typical optical absorption peak at approximately 2.30 keV and 3.0 keV corres...
Xuya Zhou1, Ying Liu1, Deqin Xu1, Jie Bao1, Yaru Cao2 and Yong Jin3*
...aperitoneal injection of streptozotocin. The adjuvant-induced arthritis model was established by Paraffin/BCG. We used western blot to explore the protein expression levels of COX-2 and cytochrome P450 (CYP) 4A1. The expression of CYP4A1 was detected by immunohistochemistry. Enzyme-linked immunosorbent assay (Elisa) was used to detect the prostaglandin E2 (PGE-2), 20-Hydroxyeicosatetraenoic acid (20-HETE), endothelin 1 (ET-1) and B-type natriuretic peptide (BN...
Ying Liu1, Shankun Liu1, Hui Wang2 and Weihua Su2,*
...caffeic acid against the streptozotocin induced GDM in rats and explores the possible mechanism of action. A total 36 female rats were caged into the male rats for the pregnancy, and 33 female pregnant rats were collected and weight. The female rats were group into following groups and each group contains 6 rats. Once the pregnancy was verified, the streptozotocin (STZ) single intraperitoneal injection was used for the induc...
Rana A. Ali1, Abd-Elraheim A. Elshater2, Heba A. Mohammed3*, Mahmoud Elshazly4
Wei Cui1, Yanwei Du1, Lijuan Jiang1, Yan Wei1, Yuguo Li1, Wenfeng Zhang1* and Ling Zhang2*
...gar diet and low dose of streptozotocin for 4 weeks to observe the body weight, fasting blood glucose, etc. The pathological changes of hippocampal CA1 region were observed through hematoxylin-eosin staining, and the expression of related proteins was detected. The results showed that, after BHD intervention, the degree of apoptosis of PC12 cells injured by HG was significantly reduced, and the cell proliferation was significantly increased. In model group, bl...
Saydat Saad Abd El-Megeed1, Walaa Yehia El-Sayed1*, Tarek Khamis2
... Diabetes was induced by streptozotocin (STZ) -nicotinamide in rats, and some biochemical and molecular parameters were determined. The results revealed that ZnO NPs in combination with Empagliflozin suggestively declined the blood glucose levels, lipid profile, and liver and kidney functions. A reduction was recorded in malondialdehyde (MDA), as well as improved catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD). A reduction was foun...
Ali Mosa Rashid Al-Yasari1, Zahid I. Mohammed2, Haider S. Almnehlawi3,4, Ali F Bargooth5, Nawar Jasim Alsalih1, Huda F. Hasan6*, Mohenned A Alsaadawi1
...ed one (ip) injection of streptozotocin (40 mg/kg), and the STZ-diabetes+Camels’ Milk group received a STZ injection (40 mg/kg) along with daily (ad libitum) bottled camel milk for 28 days. Zero time, one day, one week, two weeks, three weeks, and day 28 following STZ injection were used to monitor fasting blood glucose, insulin, and glucagon. Animals were sacrificed on day 28, and tissues were collected for immunohistochemical identification of pancreat...
Xiangmei Chen, Burie Bao* and Mo Degema
Eman Ali Hussein1*, Majdy Faisal Majeed2
.... It has been shown that streptozotocin (SZ)-induced oxidative stress damages pancreatic beta cells and results in hyperglycemia in rats, which leads to diabetic nephropathy. The goal of this investigation was to see if Trigonella foenum-graecum (TFG) flavonoid extract could protect the kidneys from the effects of (SZ). The goal of the current study was to determine if the ethanolic extract of (TFG) exhibited antioxidant activity against nephropathy resulting ...
Idrissi Ouedrhiri Housna1, Bikri Samir1,2*, Benloughmari Douae1, Aboussaleh Youssef1
...aperitoneal injection of streptozotocin (STZ). Stress symptoms were induced using the chronic immobilization stress paradigm. Anxiety and depression-related behaviors were evaluated using three behavioral tests after treatment periods of 30 days (T1) and 60 days (T2), respectively. Blood samples collected post-sacrifice were analyzed to assess lipid parameters and corticosterone (CORT) levels. Additionally, organs (pancreas and brain) were dissected to measure...
Sana Eijaz, Asmat Salim* and Mohammad Anwar Waqar
... using high fat diet and streptozotocin and treated with the extracts. Glucose level and body weight was checked throughout the study. The expression of insulin signaling genes was observed in skeletal muscle and adipose tissue by performing RT-PCR. Moreover, the level of adipokines was measured by using ELISA. Data was analyzed by t-test and One-way ANOVA using SPSS. Significant improvement was observed in the blood glucose level and body weight of diabetic r...
Bassant Mahmoud Emam1, Jehan Abd Elrazek Hassanen1, Abeer Gaffer Ali Hassan3, Azza Mahmoud Abdullah1, Hadeer Said Aboelnaga2, Amina Ali Dessouki2*
...d hepatic alterations of streptozotocin (STZ)-provoked DM rats. Here, DM was triggered by administrating 10% fructose (Fr) for two weeks, then intraperitoneally injected with a single STZ dosage (40 mg/kg). The study was carried out using 50 male albino rats allocated into 5 groups (n = 10/group): Control, diabetic non-treated, and diabetic groups treated by DAPA (1 mg/Kg b.wt), FSE (250 mg/kg, b.wt) and FSP (100mg/kg, b.wt). All doses were daily administered ...
Manan Kumar1, Sony Eka Nugraha2*, Nabila Nabila3
...aperitoneal injection of streptozotocin at a dose of 65 mg/kg body weight (BW), which was administered 15 min after the administration of nicotinamide at 110 mg/kg body weight. Diabetic rats were subsequently administered varying doses of Beta vulgaris L. ethanol extract (100, 200, and 400 mg/kg BW) for 21 days, following which blood samples were obtained to evaluate hematological parameters, and statistical analysis was conducted using ANOVA followed by Tukey...
Wassan Mhammed Husain1*, Israa J. Mohammad2, Dahlia N Al-Saidi1
