Zartasha Anjum1*, Rakhshindah Bajwa2 and Munazza Hassan3
...ation therapy along with tamoxifen in estrogen receptor (ER) and HMG-COAR positive breast carcinomas. However, in our local population, expression of HMG-COAR is not investigated. The objective of our study was to examine the expression of HMG-CoAR in primary breast carcinomas and determine its association with ER/PR expression.
Material & Methods: Cross-sectional analytical study was conducted to examine the immunohistochemical expressi...
Rukhsana Anwar1*, Ammara Abd-Us-Sattar1, Afifa Noor2, Kanwal Ashiq1,3 and Shah Jahan4
...icin, dexamethasone, and tamoxifen were selected as CYP450 modulators. In a sub-acute in vivo study, 200 mg/kg BW of both extracts were orally administered once daily for 19 days to different groups of rats. CYP modulators were administered to respective groups for last 5 consecutive days. Real-time PCR analysis of hepatic CYP450 subtypes, CYP1A2, CYP2C9, and CYP3A4 was carried out. Moreover, phase II drug-metabolizing enzymes; GST-specific activity, total glu...
Usama Bin Naeem1, Muhammad Adil Rasheed1*, Muhammad Ashraf1 and Muhammad Yasir Zahoor2
...roliferative activity of tamoxifen (TAM) and ivermectin (IVM) loaded chitosan (Cs) nanoparticles against breast cancer cell line (MCF-7) to improve drug delivery to the target sites. Characterization of NPs were carried out by Fourier transform infrared spectroscopy, zeta sizer, potential, morphology by scanning electron microscope, drug entrapment efficiency and in vitro drug release. In TAM and IVM loaded chitosan nanoparticles the peaks were at 1606 cm-1 an...
